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BTK 抗体 (AA 396-430)

Name: BTK 抗体 (AA 396-430)
SKU: ABIN6243554
Availability: OutOfStock

BTK 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB50770 unconjugated

Western blot analysis of lysates from Raji, Ramos, K562 cell line and mouse spleen tissue lysate(from left to right), using BTK Antibody (Center) (ABIN6243554 and ABIN6577451). (BTK 抗体 (AA 396-430))

Western blot analysis of lysates from Raji, Ramos, K562, Daudi cell line and mouse spleen tissue lysate(from left to right), using BTK Antibody (Center) (ABIN6243554 and ABIN6577451). (BTK 抗体 (AA 396-430))

2 images

产品编号 ABIN6243554

发货至: 中国

Datasheet as PDF

抗原 See all BTK 抗体

BTK (Bruton Agammaglobulinemia tyrosine Kinase (BTK))
抗原表位
42

16

15

14

9

9

8

7

7

7

6

5

4

3

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 396-430
适用
140

94

78

14

6

4

2
人, 小鼠
宿主
158

13
兔
Compatible Secondaries
克隆类型
148

24
多克隆
标记
65

14

10

7

6

6

6

6

6

6

4

3

3

3

3

3

3

3

3

3

3

3

3
This BTK antibody is un-conjugated
应用范围
107

64

43

40

40

18

18

16

10

10

9

3

2

2

1
Western Blotting (WB)

预测反应

C

纯化方法

This antibody is purified through a protein A column, followed by peptide affinity purification.

免疫原

This BTK antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 396-430 amino acids from the Central region of human BTK.

克隆位点

RB50770

亚型

Ig Fraction

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anti-Bruton Agammaglobulinemia tyrosine Kinase (BTK) (C-Term) antibody
BTK 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

应用备注

WB: 1:1000. WB: 1:1000

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

有效期

6 months
抗原

BTK (Bruton Agammaglobulinemia tyrosine Kinase (BTK))

别名

BTK (BTK 产品)

别名

BTK antibody, atk antibody, bpk antibody, xla antibody, imd1 antibody, agmx1 antibody, psctk1 antibody, AGMX1 antibody, AT antibody, ATK antibody, BPK antibody, IMD1 antibody, PSCTK1 antibody, XLA antibody, AI528679 antibody, xid antibody, Bruton tyrosine kinase antibody, Bruton agammaglobulinemia tyrosine kinase antibody, BTK antibody, btk antibody, Btk antibody

背景

Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK. BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways. Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway. The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense. Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells. Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation. BTK plays also a critical role in transcription regulation. Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes. BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B. Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR. GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression. ARID3A and NFAT are other transcriptional target of BTK. BTK is required for the formation of functional ARID3A DNA-binding complexes. There is however no evidence that BTK itself binds directly to DNA. BTK has a dual role in the regulation of apoptosis.

分子量

76281

UniProt

Q06187

途径

Fc-epsilon Receptor Signaling Pathway, Hormone Transport, Activation of Innate immune Response, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades, BCR Signaling