XIAP 抗体
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- 抗原 See all XIAP 抗体
- XIAP (X-Linked Inhibitor of Apoptosis (XIAP))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This XIAP antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 纯化方法
- This antibody is purified through a protein G column, followed by dialysis against PBS.
- 免疫原
- This XIAP antibody is generated from a mouse immunized with a recombinant protein human XIAP .
- 克隆位点
- 1020CT7-2-2
- 亚型
- IgG1 kappa
- Top Product
- Discover our top product XIAP Primary Antibody
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anti-X-Linked Inhibitor of Apoptosis (XIAP) (pSer87) antibody
XIAP 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-X-Linked Inhibitor of Apoptosis (XIAP) (C-Term) antibodyKO Validated XIAP 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-X-Linked Inhibitor of Apoptosis (XIAP) (AA 201-330) antibodyXIAP 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), FACS, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-X-Linked Inhibitor of Apoptosis (XIAP) (AA 1-497) antibodyXIAP 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-X-Linked Inhibitor of Apoptosis (XIAP) (AA 1-497) antibodyXIAP 适用: 人 WB, IF, PLA 宿主: 兔 Polyclonal unconjugated
anti-X-Linked Inhibitor of Apoptosis (XIAP) (AA 51-150) antibodyXIAP 适用: 人 WB, ELISA, IF, PLA 宿主: 小鼠 Monoclonal 1F4 unconjugated
anti-X-Linked Inhibitor of Apoptosis (XIAP) (AA 1-268) antibodyXIAP 适用: 人 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 4C12G10 unconjugated
anti-X-Linked Inhibitor of Apoptosis (XIAP) (AA 1-30) antibodyXIAP 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-X-Linked Inhibitor of Apoptosis (XIAP) (AA 1-497) antibodyXIAP 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-X-Linked Inhibitor of Apoptosis (XIAP) (AA 1-200) antibodyXIAP 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- IF: 1:25. WB: 1:1000-1:4000. IHC-P: 1:25
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 有效期
- 6 months
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- 抗原
- XIAP (X-Linked Inhibitor of Apoptosis (XIAP))
- 别名
- XIAP (XIAP 产品)
- 别名
- API3 antibody, BIRC4 antibody, IAP-3 antibody, ILP1 antibody, MIHA antibody, XLP2 antibody, hIAP-3 antibody, hIAP3 antibody, api3 antibody, birc4 antibody, ilp1 antibody, miha antibody, xlp2 antibody, xxiap antibody, 1110015C02Rik antibody, Aipa antibody, Api3 antibody, Birc4 antibody, IAP3 antibody, ILP-1 antibody, mXIAP antibody, riap3 antibody, fb73d01 antibody, wu:fb73d01 antibody, zgc:91873 antibody, BIRC8 antibody, X-linked inhibitor of apoptosis antibody, X-linked inhibitor of apoptosis L homeolog antibody, XIAP antibody, xiap antibody, xiap.L antibody, Xiap antibody
- 背景
- Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis. Acts as a direct caspase inhibitor. Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry. Inactivates CASP9 by keeping it in a monomeric, inactive state. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and the target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, CASP3, CASP7, CASP8, CASP9, MAP3K2/MEKK2, DIABLO/SMAC, AIFM1, CCS and BIRC5/survivin. Ubiquitinion of CCS leads to enhancement of its chaperone activity toward its physiologic target, SOD1, rather than proteasomal degradation. Ubiquitinion of MAP3K2/MEKK2 and AIFM1 does not lead to proteasomal degradation. Plays a role in copper homeostasis by ubiquitinationg COMMD1 and promoting its proteasomal degradation. Can also function as E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Regulates the BMP signaling pathway and the SMAD and MAP3K7/TAK1 dependent pathways leading to NF-kappa-B and JNK activation. Acts as an important regulator of innate immune signaling via regulation of Nodlike receptors (NLRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Acts as a positive regulator of Wnt signaling and ubiquitinates TLE1, TLE2, TLE3, TLE4 and AES. Ubiquitination of TLE3 results in inhibition of its interaction with TCF7L2/TCF4 thereby allowing efficient recruitment and binding of the transcriptional coactivator beta- catenin to TCF7L2/TCF4 that is required to initiate a Wnt-specific transcriptional program.
- 分子量
- 56685
- UniProt
- P98170
- 途径
- Apoptosis, Caspase Cascade in Apoptosis, Transition Metal Ion Homeostasis
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