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TRIP12 抗体 (AA 991-1023)

TRIP12 适用: 人 WB 宿主: 兔 Polyclonal RB54123 unconjugated
产品编号 ABIN6242961
发货至: 中国
  • 抗原 See all TRIP12 抗体
    TRIP12 (Thyroid Hormone Receptor Interactor 12 (TRIP12))
    抗原表位
    • 2
    • 2
    • 2
    • 1
    • 1
    AA 991-1023
    适用
    • 7
    • 3
    • 3
    • 1
    • 1
    • 1
    宿主
    • 7
    克隆类型
    • 7
    多克隆
    标记
    • 7
    This TRIP12 antibody is un-conjugated
    应用范围
    • 6
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB)
    预测反应
    B, Zf, M, Rat
    纯化方法
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    免疫原
    This TRIP12 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 991-1023 amino acids from the Central region of human TRIP12.
    克隆位点
    RB54123
    亚型
    Ig Fraction
    Top Product
    Discover our top product TRIP12 Primary Antibody
  • 应用备注
    WB: 1:2000
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    有效期
    6 months
  • 抗原
    TRIP12 (Thyroid Hormone Receptor Interactor 12 (TRIP12))
    别名
    TRIP12 (TRIP12 产品)
    别名
    ULF antibody, TRIP-12 antibody, 1110036I07Rik antibody, 6720416K24Rik antibody, AA410158 antibody, Gtl6 antibody, thyroid hormone receptor interactor 12 antibody, E3 ubiquitin-protein ligase TRIP12 antibody, TRIP12 antibody, CpipJ_CPIJ012812 antibody, PTRG_06487 antibody, LOAG_11488 antibody, LOC100631469 antibody, Trip12 antibody
    背景
    E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardeless of the presence of lysine residues in target proteins. In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress. In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation. Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A. Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation. Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins. Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes.
    分子量
    220434
    UniProt
    Q14669
    途径
    Nuclear Hormone Receptor Binding
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