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STUB1 抗体

STUB1 适用: 人, 小鼠 WB 宿主: 小鼠 Monoclonal 1008CT12-4-1 unconjugated
产品编号 ABIN6242870
发货至: 中国
  • 抗原 See all STUB1 抗体
    STUB1 (STIP1 Homology and U-Box Containing Protein 1 (STUB1))
    适用
    • 70
    • 43
    • 40
    • 6
    • 6
    • 4
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    • 3
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    • 2
    • 1
    • 1
    • 1
    • 1
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    • 1
    人, 小鼠
    宿主
    • 64
    • 4
    • 2
    小鼠
    克隆类型
    • 59
    • 11
    单克隆
    标记
    • 33
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    • 2
    • 1
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    • 1
    • 1
    • 1
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    This STUB1 antibody is un-conjugated
    应用范围
    • 51
    • 23
    • 13
    • 13
    • 12
    • 11
    • 11
    • 7
    • 5
    • 3
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB)
    纯化方法
    This antibody is purified through a protein G column, followed by dialysis against PBS.
    免疫原
    This STUB1 antibody is generated from a mouse immunized with a recombinant protein of human STUB1.
    克隆位点
    1008CT12-4-1
    亚型
    IgG1 kappa
    Top Product
    Discover our top product STUB1 Primary Antibody
  • 应用备注
    WB: 1:4000
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    有效期
    6 months
  • 抗原
    STUB1 (STIP1 Homology and U-Box Containing Protein 1 (STUB1))
    别名
    STUB1 (STUB1 产品)
    背景
    E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. Mediates polyubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF- BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. Mediates polyubiquitination of CYP3A4. Ubiquitinates EPHA2 and may regulate the receptor stability and activity through proteasomal degradation.
    分子量
    34856
    UniProt
    Q9UNE7
    途径
    Regulation of Hormone Metabolic Process, Response to Water Deprivation
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