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- 抗原 See all BRCA2 抗体
- BRCA2 (Breast Cancer 2, Early Onset (BRCA2))
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抗原表位
- AA 251-495
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This BRCA2 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 纯化方法
- This antibody is purified through a protein G column, followed by dialysis against PBS.
- 免疫原
- This BRCA2 antibody is generated from a mouse immunized with a recombinant protein between 251-495 amino acids from human BRCA2.
- 克隆位点
- 1643CT739-91-87
- 亚型
- IgG1 kappa
- Top Product
- Discover our top product BRCA2 Primary Antibody
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anti-Breast Cancer 2, Early Onset (BRCA2) (AA 21-130) antibody
BRCA2 适用: 人 WB, ELISA, IHC (p), IHC (fro), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Breast Cancer 2, Early Onset (BRCA2) antibodyBRCA2 适用: 人, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Breast Cancer 2, Early Onset (BRCA2) (AA 2990-3232) antibodyBRCA2 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Breast Cancer 2, Early Onset (BRCA2) (AA 3319-3418) antibodyBRCA2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3D12 unconjugated
anti-Breast Cancer 2, Early Onset (BRCA2) (AA 1-300) antibodyBRCA2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Breast Cancer 2, Early Onset (BRCA2) (AA 2913-3151) antibodyBRCA2 适用: 大鼠 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Breast Cancer 2, Early Onset (BRCA2) (AA 2308-2537) antibodyBRCA2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Breast Cancer 2, Early Onset (BRCA2) (AA 2737-2874) antibodyBRCA2 适用: 斑马鱼 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Breast Cancer 2, Early Onset (BRCA2) (pSer3291) antibodyBRCA2 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Breast Cancer 2, Early Onset (BRCA2) (N-Term) antibodyBRCA2 适用: 人, 大鼠, 猴 WB, IHC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB: 1:2000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 有效期
- 6 months
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- 抗原
- BRCA2 (Breast Cancer 2, Early Onset (BRCA2))
- 别名
- BRCA2 (BRCA2 产品)
- 背景
- Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks, together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and DSS1, and is required to prevent R-loop- associated DNA damage and thus transcription-associated genomic instability. Silencing of BRCA2 promotes R-loop accumulation at actively transcribed genes in replicating and non-replicating cells, suggesting that BRCA2 mediates the control of R-loop associated genomic instability, independently of its known role in homologous recombination (PubMed:< a href="http://www.uniprot.org/citations/24896180" target="_blank">24896180).
- 分子量
- 384202
- UniProt
- P51587
- 途径
- DNA Damage Repair, M Phase, Maintenance of Protein Location
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