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Nischarin 抗体 (AA 5-38)

NISCH 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB55910 unconjugated
产品编号 ABIN6242733
发货至: 中国
  • 抗原 See all Nischarin (NISCH) 抗体
    Nischarin (NISCH)
    抗原表位
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 5-38
    适用
    • 8
    • 3
    • 1
    人, 小鼠
    宿主
    • 7
    • 3
    克隆类型
    • 7
    • 3
    多克隆
    标记
    • 10
    This Nischarin antibody is un-conjugated
    应用范围
    • 8
    • 5
    • 4
    • 3
    • 2
    • 1
    Western Blotting (WB)
    纯化方法
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    免疫原
    This NISCH antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 5-38 amino acids from human NISCH.
    克隆位点
    RB55910
    亚型
    Ig Fraction
    Top Product
    Discover our top product NISCH Primary Antibody
  • 应用备注
    WB: 1:2000
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    有效期
    6 months
  • 抗原
    Nischarin (NISCH)
    别名
    NISCH (NISCH 产品)
    别名
    NISCH antibody, IRAS antibody, 1200007D05Rik antibody, 3202002H23Rik antibody, AW494485 antibody, I-1 antibody, IR1 antibody, hIRAS antibody, nischarin antibody, nischarin S homeolog antibody, NISCH antibody, Cyan7822_6841 antibody, nisch.S antibody, nisch antibody, Nisch antibody
    背景
    Acts either as the functional imidazoline-1 receptor (I1R) candidate or as a membrane-associated mediator of the I1R signaling. Binds numerous imidazoline ligands that induces initiation of cell-signaling cascades triggering to cell survival, growth and migration. Its activation by the agonist rilmenidine induces an increase in phosphorylation of mitogen-activated protein kinases MAPK1 and MAPK3 in rostral ventrolateral medulla (RVLM) neurons that exhibited rilmenidine-evoked hypotension (By similarity). Blocking its activation with efaroxan abolished rilmenidine-induced mitogen-activated protein kinase phosphorylation in RVLM neurons (By similarity). Acts as a modulator of Rac-regulated signal transduction pathways (By similarity). Suppresses Rac1-stimulated cell migration by interacting with PAK1 and inhibiting its kinase activity (By similarity). Also blocks Pak-independent Rac signaling by interacting with RAC1 and inhibiting Rac1-stimulated NF-kB response element and cyclin D1 promoter activation (By similarity). Inhibits also LIMK1 kinase activity by reducing LIMK1 'Tyr-508' phosphorylation (By similarity). Inhibits Rac-induced cell migration and invasion in breast and colon epithelial cells (By similarity). Inhibits lamellipodia formation, when overexpressed (By similarity). Plays a role in protection against apoptosis. Involved in association with IRS4 in the enhancement of insulin activation of MAPK1 and MAPK3. When overexpressed, induces a redistribution of cell surface ITGA5 integrin to intracellular endosomal structures.
    分子量
    166629
    UniProt
    Q9Y2I1
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