-
- 抗原 See all RBM8A 抗体
- RBM8A (RNA Binding Motif Protein 8A (RBM8A))
-
抗原表位
- AA 79-112
-
适用
- 小鼠
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- This RBM8A antibody is un-conjugated
-
应用范围
- Western Blotting (WB)
- 预测反应
- X, B, Rat
- 纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- 免疫原
- This RBM8A antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 79-112amino acids from the Central region of human RBM8A.
- 克隆位点
- RB49687
- 亚型
- Ig Fraction
- Top Product
- Discover our top product RBM8A Primary Antibody
-
anti-RNA Binding Motif Protein 8A (RBM8A) antibody
RBM8A 适用: 人, 大鼠, 小鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-RNA Binding Motif Protein 8A (RBM8A) antibodyRBM8A 适用: 人, 非洲爪蟾 WB, ELISA, IF, IHC (p), ICC, FACS, IP 宿主: 小鼠 Monoclonal 4C4 unconjugated
anti-RNA Binding Motif Protein 8A (RBM8A) (AA 1-174) antibodyRBM8A 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 3E4 unconjugated
anti-RNA Binding Motif Protein 8A (RBM8A) (N-Term) antibodyRBM8A 适用: 人, 大鼠, 小鼠, 斑马鱼, Cow, 犬, 马, Pig, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-RNA Binding Motif Protein 8A (RBM8A) (N-Term) antibodyRBM8A 适用: 人, 大鼠, 小鼠, 斑马鱼, Cow, 犬, 马, 非洲爪蟾, Pig, 兔, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-RNA Binding Motif Protein 8A (RBM8A) (AA 1-175) antibodyRBM8A 适用: 人 WB, ELISA, IHC, IHC (p) 宿主: 小鼠 Monoclonal 3E4 unconjugated
anti-RNA Binding Motif Protein 8A (RBM8A) (N-Term) antibodyRBM8A 适用: 人, 大鼠, 小鼠, 斑马鱼, 犬 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-RNA Binding Motif Protein 8A (RBM8A) (AA 212-553) antibodyRBM8A 适用: E. coli WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-RNA Binding Motif Protein 8A (RBM8A) antibodyRBM8A 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
-
- 应用备注
- WB: 1:1000
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 有效期
- 6 months
-
- 抗原
- RBM8A (RNA Binding Motif Protein 8A (RBM8A))
- 别名
- RBM8A (RBM8A 产品)
- 别名
- BOV-1A antibody, BOV-1B antibody, BOV-1C antibody, C1DELq21.1 antibody, DEL1q21.1 antibody, MDS014 antibody, RBM8 antibody, RBM8B antibody, TAR antibody, Y14 antibody, ZNRP antibody, ZRNP1 antibody, 2310057C03Rik antibody, AA673428 antibody, Rbm8 antibody, RBM8A antibody, rbm8 antibody, rbm8a antibody, rnp-5 antibody, fb34f03 antibody, wu:fb34f03 antibody, zgc:110525 antibody, rbm8-A antibody, rbm8a-A antibody, rbm8-B antibody, RNA binding motif protein 8A antibody, RNA binding motif protein 8a antibody, RNA binding motif protein 8A S homeolog antibody, RNA binding motif protein 8A L homeolog antibody, RBM8A antibody, Rbm8a antibody, rbm8a antibody, rbm8a.S antibody, rbm8a.L antibody
- 背景
- Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP- bound EJC core onto spliced mRNA in a stable conformation. The MAGOH-RBM8A heterodimer interacts with the EJC key regulator WIBG/PYM leading to EJC disassembly in the cytoplasm and translation enhancement of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex. Its removal from cytoplasmic mRNAs requires translation initiation from EJC-bearing spliced mRNAs. Associates preferentially with mRNAs produced by splicing. Does not interact with pre-mRNAs, introns, or mRNAs produced from intronless cDNAs. Associates with both nuclear mRNAs and newly exported cytoplasmic mRNAs. The MAGOH-RBM8A heterodimer is a component of the nonsense mediated decay (NMD) pathway. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes), specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S), the function is different from the established EJC assembly.
- 分子量
- 19889
- UniProt
- Q9Y5S9
-
You are here:
