HRCA1 antibody, RCA1 antibody, TRC8 antibody, 4930555P18Rik antibody, zgc:175173 antibody, rnf139 antibody, ring finger protein 139 antibody, ring finger protein 139 S homeolog antibody, RNF139 antibody, Rnf139 antibody, rnf139 antibody, rnf139.S antibody
背景
E3-ubiquitin ligase, acts as a negative regulator of the cell proliferation through mechanisms involving G2/M arrest and cell death. Required for MHC class I ubiquitination in cells expressing the cytomegalovirus protein US2 before dislocation from the endoplasmic reticulum (ER). Affects SREBP processing by hindering the SREBP/SCAP complex translocation from the ER to the Golgi, thereby reducing SREBF2 target gene expression. Required for INSIG1 ubiquitination. May be required for EIF3 complex ubiquitination. May function as a signaling receptor.