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PTEN 抗体 (N-Term)

Name: PTEN 抗体 (N-Term)
SKU: ABIN6242544
Availability: OutOfStock

PTEN 适用: 人, 小鼠, 大鼠 WB 宿主: 小鼠 Monoclonal 1096CT4-3-3 unconjugated

All lanes : Anti-PTEN Antibody (N-term) at 1:500-1:2000 dilution Lane 1: Hela whole cell lysate Lane 2: C6 whole cell lysate Lane 3: NIH/3T3 whole cell lysate Lysates/proteins at 20 μg per lane. (PTEN 抗体 (N-Term))

1 image

产品编号 ABIN6242544

发货至: 中国

Datasheet as PDF

抗原 See all PTEN 抗体

PTEN (Phosphatase and Tensin Homolog (PTEN))
抗原表位
18

17

16

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1
AA 10-44, N-Term

适用

人, 小鼠, 大鼠
宿主
46
小鼠
Compatible Secondaries
克隆类型
46
单克隆
标记
31

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
This PTEN antibody is un-conjugated
应用范围
25

21

15

14

13

13

6

5

3

3
Western Blotting (WB)

预测反应

X

纯化方法

This antibody is purified through a protein G column, followed by dialysis against PBS.

免疫原

This PTEN antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 10-44 amino acids from the N-terminal region of human PTEN.

克隆位点

1096CT4-3-3

亚型

IgG1 kappa

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anti-Phosphatase and Tensin Homolog (PTEN) (AA 69-104), (N-Term) antibody
PTEN 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB05082 unconjugated

anti-Phosphatase and Tensin Homolog (PTEN) (AA 69-104) antibody
PTEN 适用: 人 WB, ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated

anti-Phosphatase and Tensin Homolog (PTEN) (AA 264-295), (C-Term) antibody
PTEN 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB5083 unconjugated

anti-Phosphatase and Tensin Homolog (PTEN) (AA 306-335) antibody
PTEN 适用: 人 WB, ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated

anti-Phosphatase and Tensin Homolog (PTEN) (AA 264-295) antibody
PTEN 适用: 人 WB, ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated

anti-Phosphatase and Tensin Homolog (PTEN) (AA 363-392) antibody
PTEN 适用: 人 WB 宿主: 兔 Polyclonal RB39439 unconjugated

anti-Phosphatase and Tensin Homolog (PTEN) (AA 371-403) antibody
PTEN 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-Phosphatase and Tensin Homolog (PTEN) (AA 361-390) antibody
PTEN 适用: 人 WB 宿主: 兔 Polyclonal RB39430 unconjugated

anti-Phosphatase and Tensin Homolog (PTEN) (pSer294) antibody
PTEN 适用: 人 DB 宿主: 兔 Polyclonal RB39738 unconjugated

anti-Phosphatase and Tensin Homolog (PTEN) (pSer229) antibody
PTEN 适用: 人 DB 宿主: 兔 Polyclonal RB39748 unconjugated

应用备注

WB: 1:500-1:2000

限制

仅限研究用
状态

Liquid

缓冲液

Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

有效期

6 months
抗原

PTEN (Phosphatase and Tensin Homolog (PTEN))

别名

PTEN (PTEN 产品)

别名

10q23del antibody, BZS antibody, CWS1 antibody, DEC antibody, GLM2 antibody, MHAM antibody, MMAC1 antibody, PTEN1 antibody, TEP1 antibody, 2310035O07Rik antibody, A130070J02Rik antibody, AI463227 antibody, B430203M17Rik antibody, Mmac antibody, PTENP1 antibody, wu:fc52g04 antibody, zgc:73086 antibody, fa11a08 antibody, fb73f10 antibody, fc83f12 antibody, fd16b10 antibody, fk90e11 antibody, pten antibody, si:bz1g13.4 antibody, wu:fa11a08 antibody, wu:fb73f10 antibody, wu:fc83f12 antibody, wu:fd16b10 antibody, wu:fk90e11 antibody, phosphatase and tensin homolog antibody, phosphatase and tensin homolog L homeolog antibody, phosphatase and tensin homolog A antibody, phosphatase and tensin homolog B antibody, PTEN antibody, Pten antibody, pten.L antibody, ptena antibody, ptenb antibody

背景

Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3- phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor suppressor function. Antagonizes the PI3K- AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form cooperates with AIP1 to suppress AKT1 activation. Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation. Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability. In motile cells, suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement.

分子量

47166

UniProt

P60484

途径

TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Inositol Metabolic Process, Synaptic Membrane, Regulation of Cell Size, Autophagy, Platelet-derived growth Factor Receptor Signaling, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling