This antibody is purified through a protein A column, followed by peptide affinity purification.
免疫原
This Mouse Med15 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 743-779 amino acids from the C-terminal region of Mouse Med15.
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol-dependent gene regulation. Positively regulates the Nodal signaling pathway (By similarity).