This antibody is purified through a protein A column, followed by peptide affinity purification.
免疫原
This EWSR1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 639-674 amino acids from the C-terminal region of human EWSR1.
Might normally function as a transcriptionnal repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.