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E2F8 抗体 (AA 835-865)

E2F8 适用: 人 WB 宿主: 兔 Polyclonal RB54144 unconjugated
产品编号 ABIN6242297
发货至: 中国
  • 抗原 See all E2F8 抗体
    E2F8 (E2F Transcription Factor 8 (E2F8))
    抗原表位
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 835-865
    适用
    • 41
    • 24
    • 23
    • 12
    • 11
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    宿主
    • 38
    • 2
    • 1
    克隆类型
    • 39
    • 2
    多克隆
    标记
    • 17
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This E2F8 antibody is un-conjugated
    应用范围
    • 15
    • 12
    • 7
    • 4
    • 2
    • 2
    • 1
    Western Blotting (WB)
    预测反应
    M, Rat
    纯化方法
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    免疫原
    This E2F8 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 835-865 amino acids from human E2F8.
    克隆位点
    RB54144
    亚型
    Ig Fraction
    Top Product
    Discover our top product E2F8 Primary Antibody
  • 应用备注
    WB: 1:2000
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    有效期
    6 months
  • 抗原
    E2F8 (E2F Transcription Factor 8 (E2F8))
    别名
    E2F8 (E2F8 产品)
    别名
    MGC130750 antibody, E2F8 antibody, E2F-8 antibody, RGD1308091 antibody, 4432406C08Rik antibody, AA410048 antibody, E2F transcription factor 8 antibody, E2F transcription factor 8 L homeolog antibody, E2F8 antibody, e2f8.L antibody, e2f8 antibody, E2f8 antibody
    背景
    Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1: component of a feedback loop in S phase by repressing the expression of E2F1, thereby preventing p53/TP53-dependent apoptosis. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene.
    分子量
    94166
    UniProt
    A0AVK6
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