This antibody is purified through a protein A column, followed by peptide affinity purification.
免疫原
This NFE4 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 102-136 amino acids from the Central region of human NFE4.
Functions as part of the SSP (stage selector protein) complex, a complex that contributes to the preferential expression of the gamma-gene in fetal erythroid cells by facilitating the interaction of the gamma-globin genes with enhancer elements contained in the locus control region (LCR). The complex binds to the stage selector element (SSE) in the proximal gamma-globin promoter. In contrast, isoform 2 acts as a repressor of gamma- globin gene expression by preventing NFE2 and RNA polymerase II recruitment to the promoter.