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NEIL3 抗体

NEIL3 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6241838
发货至: 中国
  • 抗原 See all NEIL3 抗体
    NEIL3 (Nei Endonuclease VIII-Like 3 (NEIL3))
    适用
    人, 小鼠, 大鼠
    宿主
    • 17
    • 2
    克隆类型
    • 17
    • 2
    多克隆
    标记
    • 14
    • 1
    • 1
    • 1
    • 1
    • 1
    This NEIL3 antibody is un-conjugated
    应用范围
    • 18
    • 11
    • 5
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB)
    免疫原
    synthetic peptide
    Top Product
    Discover our top product NEIL3 Primary Antibody
  • 应用备注
    WB: 1:1000
    限制
    仅限研究用
  • 状态
    Liquid
    储存条件
    4 °C,-20 °C
  • 抗原
    NEIL3 (Nei Endonuclease VIII-Like 3 (NEIL3))
    别名
    NEIL3 (NEIL3 产品)
    背景
    DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA). In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in both ssDNA and dsDNA, also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5- OHMH, Tg and 8-oxoA lesions in ssDNA. No activity on 8-oxoG detected. Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity. In vivo, appears to be the primary enzyme involved in removing Sp and Gh from ssDNA in neonatal tissues. Seems to be an important facilitator of cell proliferation in certain populations, for example neural stem/progenitor cells and tumor cells, suggesting a role in replication-associated DNA repair.
    UniProt
    Q8TAT5
    途径
    DNA Damage Repair
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