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CRTC1 抗体

CRTC1 适用: 人 WB, IP, FACS, ICC 宿主: 小鼠 Monoclonal unconjugated
产品编号 ABIN6241239
发货至: 中国
  • 抗原 See all CRTC1 抗体
    CRTC1 (CREB Regulated Transcription Coactivator 1 (CRTC1))
    适用
    • 58
    • 28
    • 23
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    • 4
    • 3
    • 3
    • 3
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    • 2
    • 1
    • 1
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    宿主
    • 49
    • 10
    • 1
    小鼠
    克隆类型
    • 49
    • 11
    单克隆
    标记
    • 30
    • 4
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    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
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    • 1
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    This CRTC1 antibody is un-conjugated
    应用范围
    • 50
    • 25
    • 20
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    • 8
    • 7
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    • 5
    • 5
    • 3
    • 1
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    Western Blotting (WB), Immunoprecipitation (IP), Flow Cytometry (FACS), Immunocytochemistry (ICC)
    免疫原
    Recombinant Protein
    Top Product
    Discover our top product CRTC1 Primary Antibody
  • 应用备注
    IP: 1:500. WB: 1:1000. FC: 1:100. ICC: 1:300
    限制
    仅限研究用
  • 状态
    Liquid
    储存条件
    4 °C,-20 °C
  • 抗原
    CRTC1 (CREB Regulated Transcription Coactivator 1 (CRTC1))
    别名
    MECT1 / Torc1 (CRTC1 产品)
    背景
    Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). In the hippocampus, involved in late-phase long- term potentiation (L-LTP) maintenance at the Schaffer collateral- CA1 synapses. May be required for dendritic growth of developing cortical neurons (By similarity). In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock.
    UniProt
    Q6UUV9
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