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beta Catenin 抗体 (pSer33, pSer37)

CATNB 适用: 人 WB 宿主: 兔 Polyclonal RB42029 unconjugated
产品编号 ABIN6241068
发货至: 中国
  • 抗原 See all beta Catenin (CATNB) 抗体
    beta Catenin (CATNB) (Catenin, beta (CATNB))
    抗原表位
    • 49
    • 27
    • 25
    • 25
    • 23
    • 19
    • 17
    • 17
    • 16
    • 16
    • 16
    • 15
    • 10
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    • 7
    • 3
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    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 19-41, pSer33, pSer37
    适用
    • 343
    • 255
    • 232
    • 27
    • 23
    • 22
    • 18
    • 16
    • 7
    • 5
    • 5
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    宿主
    • 286
    • 57
    • 4
    • 1
    • 1
    克隆类型
    • 279
    • 70
    多克隆
    标记
    • 130
    • 22
    • 11
    • 10
    • 9
    • 9
    • 9
    • 9
    • 9
    • 9
    • 9
    • 9
    • 9
    • 9
    • 9
    • 8
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    This beta Catenin antibody is un-conjugated
    应用范围
    • 214
    • 159
    • 120
    • 118
    • 80
    • 64
    • 62
    • 52
    • 34
    • 32
    • 24
    • 9
    • 7
    • 4
    • 1
    Western Blotting (WB)
    预测反应
    B, Zf, M, Rat, X
    纯化方法
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    免疫原
    This Phospho-beta-catenin (Ser33/37) antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 19-41 amino acids from human beta-catenin .
    克隆位点
    RB42029
    亚型
    Ig Fraction
    Top Product
    Discover our top product CATNB Primary Antibody
  • 应用备注
    WB: 1:1000
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    有效期
    6 months
  • Zhuang, Wang, Wang, Ma, Han, Zou, Wu, Dong, Qu, Zang, Wu: "MicroRNA-23b functions as an oncogene and activates AKT/GSK3β/β-catenin signaling by targeting ST7L in hepatocellular carcinoma." in: Cell death & disease, Vol. 8, Issue 5, pp. e2804, (2018) (PubMed).

  • 抗原
    beta Catenin (CATNB) (Catenin, beta (CATNB))
    别名
    beta-catenin (CATNB 产品)
    别名
    Bfc antibody, Catnb antibody, Mesc antibody, CTNNB antibody, MRD19 antibody, armadillo antibody, ctnnb antibody, id:ibd2058 antibody, wu:fb73e10 antibody, wu:fi81c06 antibody, wu:fk25h01 antibody, beta-catenin antibody, ctnnb1 antibody, CHBCAT antibody, catenin (cadherin associated protein), beta 1 antibody, catenin beta 1 antibody, catenin (cadherin-associated protein), beta 1 antibody, catenin beta 1 L homeolog antibody, Ctnnb1 antibody, CTNNB1 antibody, ctnnb1 antibody, ctnnb1.L antibody
    背景
    Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:< a href="http://www.uniprot.org/citations/17524503" target="_blank">17524503, PubMed:< a href="http://www.uniprot.org/citations/18077326" target="_blank">18077326, PubMed:< a href="http://www.uniprot.org/citations/18086858" target="_blank">18086858, PubMed:< a href="http://www.uniprot.org/citations/18957423" target="_blank">18957423, PubMed:< a href="http://www.uniprot.org/citations/21262353" target="_blank">21262353, PubMed:< a href="http://www.uniprot.org/citations/22647378" target="_blank">22647378, PubMed:< a href="http://www.uniprot.org/citations/22699938" target="_blank">22699938, PubMed:< a href="http://www.uniprot.org/citations/22155184" target="_blank">22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity).
    分子量
    85497
    UniProt
    P35222
    途径
    Peptide Hormone Metabolism
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