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CREB1 抗体

CREB1 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN3021674
发货至: 中国
  • 抗原 See all CREB1 抗体
    CREB1 (cAMP Responsive Element Binding Protein 1 (CREB1))
    适用
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    人, 小鼠, 大鼠
    宿主
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    克隆类型
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    多克隆
    标记
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    This CREB1 antibody is un-conjugated
    应用范围
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    Western Blotting (WB), Immunohistochemistry (IHC)
    纯化方法
    Affinity purification
    免疫原
    Recombinant protein of human CREB1
    亚型
    IgG
    Top Product
    Discover our top product CREB1 Primary Antibody
  • 应用备注
    Recommended dilutions: WB: 1:500-1:2000, IHC: 1:50-1:200
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid freeze / thaw cycles
    储存条件
    -20 °C/-80 °C
  • 抗原
    CREB1 (cAMP Responsive Element Binding Protein 1 (CREB1))
    别名
    CREB1 (CREB1 产品)
    背景
    CREB is a bZIP transcription factor that activates target genes through cAMP response elements. CREB is able to mediate signals from numerous physiological stimuli, resulting in regulation of a broad array of cellular responses. While CREB is expressed in numerous tissues, it plays a large regulatory role in the nervous system. CREB is believed to play a key role in promoting neuronal survival, precursor proliferation, neurite outgrowth, and neuronal differentiation in certain neuronal populations. Additionally, CREB signaling is involved in learning and memory in several organisms. CREB is able to selectively activate numerous downstream genes through interactions with different dimerization partners. CREB is activated by phosphorylation at Ser133 by various signaling pathways including Erk, Ca2+, and stress signaling. Some of the kinases involved in phosphorylating CREB at Ser133 are p90RSK, MSK, CaMKIV, and MAPKAPK-2.
    Synonyms: CREB1, CREB, MGC9284
    基因ID
    1385
    UniProt
    P16220
    途径
    TLR signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Thyroid Hormone Synthesis, Activation of Innate immune Response, Myometrial Relaxation and Contraction, Regulation of Cell Size, Toll-Like Receptors Cascades, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, Positive Regulation of fat Cell Differentiation
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