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FAT Atypical Cadherin 2 (FAT2) 抗体 (CF®647)

FAT2 适用: 人 IF, FACS, IHC 宿主: 小鼠 Monoclonal 8C5 CF®647
产品编号 ABIN6155399
发货至: 中国
  • 抗原 See all FAT Atypical Cadherin 2 (FAT2) 抗体
    FAT Atypical Cadherin 2 (FAT2)
    适用
    • 14
    • 1
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    宿主
    • 9
    • 5
    小鼠
    克隆类型
    • 9
    • 5
    单克隆
    标记
    • 5
    • 2
    • 1
    • 1
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    CF®647
    应用范围
    • 10
    • 9
    • 9
    • 3
    • 1
    • 1
    • 1
    • 1
    Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (IHC)
    原理
    Mouse Monoclonal anti-Protocadherin-FAT2 (8C5), CF647 Conjugate
    产品特性
    This antibody recognizes a protein of 480 kDa, which is identified as FAT2. The cadherins represent a family of Ca2 -dependent adhesion molecules that function to mediate cell-to-cell binding that is critical for the maintenance of structure and morphogenesis. Cadherins each contain a large extracellular domain at the N-terminus, which is characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity. The relatively short C-terminal intracellular domain interacts with a variety of cytoplasmic proteins, including ?-catenin, to regulate cadherin function. The cadherin superfamily includes cadherins, protocadherins, desmogleins and desmocollins. FAT2 (FAT tumor suppressor homolog 2) is a single-pass type I membrane protein that belongs to the protocadherin subfamily of cadherins. FAT2 contains one Laminin G-like domain, two EGF-like domains and 32 cadherin domains and is believed to function as a cell adhesion molecule, controlling cell proliferation and playing an important role in cerebellum development. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
    免疫原
    Purified recombinant human FAT2 fusion protein
    克隆位点
    8C5
    亚型
    IgG1 kappa
    Top Product
    Discover our top product FAT2 Primary Antibody
  • 应用备注
    Immunohistology (formalin) 0.5-1 μg/mL
    • Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer,  pH 6.0, for 10-20 min followed by cooling at RT for 20 min
    • Flow Cytometry 0.5-1 μg/million cells/0.1 mL
    • Immunofluorescence 1-2 μg/mL
    • Optimal dilution for a specific application should be determined by user
    说明

    Esophagus, Cervix, Uterus, Tonsil or Cerebellum.

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    100 μg/mL
    缓冲液
    PBS/0.1 % BSA/0.05 % azide
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Protect from light
  • 抗原
    FAT Atypical Cadherin 2 (FAT2)
    别名
    Protocadherin-FAT2 (FAT2 产品)
    别名
    EMI2 antibody, Fath2 antibody, Gm523 antibody, mKIAA0811 antibody, CDHF8 antibody, CDHR9 antibody, HFAT2 antibody, MEGF1 antibody, FAT atypical cadherin 2 antibody, Fat2 antibody, FAT2 antibody
    分子量
    480 kDa
    基因ID
    2196, 591255
    UniProt
    Q9NYQ8
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