WWTR1 抗体 (AA 1-230)
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- 抗原 See all WWTR1 抗体
- WWTR1 (WW Domain Containing Transcription Regulator 1 (WWTR1))
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抗原表位
- AA 1-230
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This WWTR1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
- 序列
- MNPASAPPPL PPPGQQVIHV TQDLDTDLEA LFNSVMNPKP SSWRKKILPE SFFKEPDSGS HSRQSSTDSS GGHPGPRLAG GAQHVRSHSS PASLQLGTGA GAAGSPAQQH AHLRQQSYDV TDELPLPPGW EMTFTATGQR YFLNHIEKIT TWQDPRKAMN QPLNHMNLHP AVSSTPVPQR SMAVSQPNLV MNHQHQQQMA PSTLSQQNHP TQNPPAGLMS MPNALTTQQQ
- 交叉反应
- 人, 小鼠, 大鼠
- 产品特性
- Polyclonal Antibodies
- 免疫原
- Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human TAZ (NP_056287.1).
- 亚型
- IgG
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anti-WW Domain Containing Transcription Regulator 1 (WWTR1) (N-Term) antibody
WWTR1 适用: 人, 小鼠, 大鼠, 犬, 兔, Cow, 豚鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-WW Domain Containing Transcription Regulator 1 (WWTR1) (AA 201-300) antibodyWWTR1 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 1F1 unconjugated
anti-WW Domain Containing Transcription Regulator 1 (WWTR1) (C-Term) antibodyWWTR1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-WW Domain Containing Transcription Regulator 1 (WWTR1) antibodyWWTR1 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-WW Domain Containing Transcription Regulator 1 (WWTR1) antibodyWWTR1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-WW Domain Containing Transcription Regulator 1 (WWTR1) (AA 296-330), (C-Term) antibodyWWTR1 适用: 人 WB 宿主: 兔 Polyclonal RB51589 unconjugated
anti-WW Domain Containing Transcription Regulator 1 (WWTR1) (AA 296-330), (C-Term) antibodyWWTR1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB51590 unconjugated
anti-WW Domain Containing Transcription Regulator 1 (WWTR1) (C-Term) antibodyWWTR1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-WW Domain Containing Transcription Regulator 1 (WWTR1) antibodyWWTR1 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200
- 说明
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HIGH QUALITY
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- 抗原
- WWTR1 (WW Domain Containing Transcription Regulator 1 (WWTR1))
- 别名
- WWTR1 (WWTR1 产品)
- 别名
- WWTR1 antibody, TAZ antibody, 2310058J06Rik antibody, 2610021I22Rik antibody, C78399 antibody, Taz antibody, WW domain containing transcription regulator 1 L homeolog antibody, WW domain containing transcription regulator 1 antibody, wwtr1.L antibody, wwtr1 antibody, WWTR1 antibody, Wwtr1 antibody
- 背景
- Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. In conjunction with YAP1, involved in the regulation of TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation. Plays a key role in coupling SMADs to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.,WW domain-containing transcription regulator protein 1,Transcriptional coactivator with PDZ-binding motif,TAZ,WWTR1,Epigenetics & Nuclear Signaling,Cell Biology & Developmental Biology,Hippo Signaling Pathway,Stem Cells,Mesenchymal Stem Cells,WWTR1
- 分子量
- 44 kDa
- 基因ID
- 25937
- UniProt
- Q9GZV5
- 途径
- Regulation of Lipid Metabolism by PPARalpha
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