TIMP-1 antibody, TIMP1 antibody, DKFZp468A0912 antibody, CLGI antibody, EPA antibody, EPO antibody, HCI antibody, TIMP antibody, Timp antibody, Clgi antibody, TIMP metallopeptidase inhibitor 1 antibody, tissue inhibitor of metalloproteinase 1 antibody, TIMP1 antibody, Timp1 antibody
背景
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction.,TIMP1,CLGI,EPA,EPO,HCI,TIMP,TIMP-1,Cancer,Invasion and Metastasis,Signal Transduction,Cell Biology & Developmental Biology,Cytoskeleton,Extracellular Matrix,Ubiquitin,Immunology & Inflammation,IL-6 Receptor Signaling Pathway,Cardiovascular,Angiogenesis,TIMP1