hRNF8 antibody, 3830404E21Rik antibody, AIP37 antibody, RNF8 antibody, rnf8 antibody, fc66f09 antibody, wu:fc66f09 antibody, zgc:55936 antibody, zgc:77313 antibody, ring finger protein 8 antibody, ring finger protein 8, E3 ubiquitin protein ligase S homeolog antibody, ring finger protein 8, E3 ubiquitin protein ligase L homeolog antibody, ring finger protein 8, E3 ubiquitin protein ligase antibody, RNF8 antibody, Rnf8 antibody, rnf8.S antibody, rnf8.L antibody, rnf8 antibody
背景
The protein encoded by this gene contains a RING finger motif and an FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes (E2), including UBE2E1/UBCH6, UBE2E2, and UBE2E3, and may act as an ubiquitin ligase (E3) in the ubiquitination of certain nuclear proteins. This protein is also known to play a role in the DNA damage response and depletion of this protein causes cell growth inhibition and cell cycle arrest. Alternative splicing results in multiple transcript variants.,RNF8,hRNF8,Epigenetics & Nuclear Signaling,Cell Biology & Developmental Biology,Ubiquitin,RNF8