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PPP1R12A 抗体 (AA 710-970)

PPP1R12A 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6146060
发货至: 中国
  • 抗原 See all PPP1R12A 抗体
    PPP1R12A (Myosin Phosphatase, Target Subunit 1 (PPP1R12A))
    抗原表位
    • 26
    • 23
    • 7
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    AA 710-970
    适用
    • 92
    • 82
    • 66
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    宿主
    • 114
    • 1
    克隆类型
    • 115
    多克隆
    标记
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    This PPP1R12A antibody is un-conjugated
    应用范围
    • 59
    • 27
    • 26
    • 26
    • 19
    • 13
    • 7
    • 6
    • 4
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    序列
    TIGRSRSTRT REQENEEKEK EEKEKQDKEK QEEKKESETS REDEYKQKYS RTYDETYQRY RPVSTSSSTT PSSSLSTMSS SLYASSQLNR PNSLVGITSA YSRGITKENE REGEKREEEK EGEDKSQPKS IRERRRPREK RRSTGVSFWT QDSDENEQEQ QSDTEEGSNK KETQTDSISR YETSSTSAGD RYDSLLGRSG SYSYLEERKP YSSRLEKDDS TDFKKLYEQI LAENEKLKAQ LHDTNMELTD LKLQLEKATQ R
    交叉反应
    人, 小鼠, 大鼠
    产品特性
    Polyclonal Antibodies
    免疫原
    Recombinant fusion protein containing a sequence corresponding to amino acids 710-970 of human PPP1R12A (NP_002471.1).
    亚型
    IgG
    Top Product
    Discover our top product PPP1R12A Primary Antibody
  • 应用备注
    WB,1:500 - 1:2000,IHC,1:50 - 1:200
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原
    PPP1R12A (Myosin Phosphatase, Target Subunit 1 (PPP1R12A))
    别名
    PPP1R12A (PPP1R12A 产品)
    别名
    1200015F06Rik antibody, 5730577I22Rik antibody, AA792106 antibody, AV099298 antibody, D10Ertd625e antibody, Mypt1 antibody, M130 antibody, MBS antibody, MYPT1 antibody, M110 antibody, MBSP antibody, protein phosphatase 1, regulatory (inhibitor) subunit 12A antibody, protein phosphatase 1 regulatory subunit 12A antibody, protein phosphatase 1, regulatory subunit 12A antibody, Ppp1r12a antibody, PPP1R12A antibody
    背景
    Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase. Several transcript variants encoding different isoforms have been found for this gene.,PPP1R12A,M130,MBS,MYPT1,MYPT1,Epigenetics & Nuclear Signaling,Signal Transduction,Kinase,Serine/threonine kinases,Cell Biology & Developmental Biology,Cell Cycle,Cytoskeleton,Motor Proteins,Actins,PPP1R12A
    分子量
    105 kDa/109 kDa/111 kDa/115 kDa
    基因ID
    4659
    UniProt
    O14974
    途径
    M Phase
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