This gene encodes the protein subunit of two different small nucleolar ribonucleoprotein complexes: the endoribonuclease for mitochondrial RNA processing complex and the ribonuclease P complex. The encoded protein is a ribonuclease that localizes to the nucleus and functions in pre-RNA processing. This protein is also an autoantigen in patients suffering from connective tissue diseases. Alternative splicing results in multiple transcript variants.,POP1,ANXD2,Epigenetics & Nuclear Signaling,RNA Binding,Endocrine & Metabolism,Mitochondrial metabolism,Immunology & Inflammation,POP1