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PMS2 抗体 (AA 390-670)

PMS2 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6145828
发货至: 中国
  • 抗原 See all PMS2 抗体
    PMS2 (PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2))
    抗原表位
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 390-670
    适用
    • 57
    • 10
    • 8
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    宿主
    • 44
    • 13
    克隆类型
    • 35
    • 22
    多克隆
    标记
    • 40
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This PMS2 antibody is un-conjugated
    应用范围
    • 34
    • 26
    • 12
    • 11
    • 6
    • 6
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)
    序列
    ADLEKPMVEK QDQSPSLRTG EEKKDVSISR LREAFSLRHT TENKPHSPKT PEPRRSPLGQ KRGMLSSSTS GAISDKGVLR PQKEAVSSSH GPSDPTDRAE VEKDSGHGST SVDSEGFSIP DTGSHCSSEY AASSPGDRGS QEHVDSQEKA PKTDDSFSDV DCHSNQEDTG CKFRVLPQPT NLATPNTKRF KKEEILSSSD ICQKLVNTQD MSASQVDVAV KINKKVVPLD FSMSSLAKRI KQLHHEAQQS EGEQNYRKFR AKICPGENQA AEDELRKEIS K
    交叉反应
    人, 小鼠
    产品特性
    Polyclonal Antibodies
    免疫原
    Recombinant fusion protein containing a sequence corresponding to amino acids 390-670 of human PMS2 (NP_000526.2).
    亚型
    IgG
    Top Product
    Discover our top product PMS2 Primary Antibody
  • 应用备注
    WB,1:500 - 1:2000,IF,1:50 - 1:200,IP,1:20 - 1:50
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原
    PMS2 (PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2))
    别名
    PMS2 (PMS2 产品)
    别名
    HNPCC4 antibody, PMS2CL antibody, PMSL2 antibody, AW555130 antibody, Pmsl2 antibody, PMS1 homolog 2, mismatch repair system component antibody, PMS1 homolog2, mismatch repair system component antibody, mismatch repair endonuclease PMS2 antibody, PMS2 antibody, Pms2 antibody, LOC463257 antibody, LOC107984056 antibody
    背景
    The protein encoded by this gene is a key component of the mismatch repair system that functions to correct DNA mismatches and small insertions and deletions that can occur during DNA replication and homologous recombination. This protein forms heterodimers with the gene product of the mutL homolog 1 (MLH1) gene to form the MutL-alpha heterodimer. The MutL-alpha heterodimer possesses an endonucleolytic activity that is activated following recognition of mismatches and insertion/deletion loops by the MutS-alpha and MutS-beta heterodimers, and is necessary for removal of the mismatched DNA. There is a DQHA(X)2E(X)4E motif found at the C-terminus of the protein encoded by this gene that forms part of the active site of the nuclease. Mutations in this gene have been associated with hereditary nonpolyposis colorectal cancer (HNPCC, also known as Lynch syndrome) and Turcot syndrome.,PMS2,HNPCC4,MLH4,PMS2CL,PMSL2,PMS2
    分子量
    20 kDa/51 kDa/62 kDa/95 kDa
    基因ID
    5395
    UniProt
    P54278
    途径
    DNA Damage Repair, Production of Molecular Mediator of Immune Response
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