This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14,21)(q11.2,q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome.,OLIG2,BHLHB1,OLIGO2,PRKCBP2,RACK17,bHLHe19,Epigenetics & Nuclear Signaling,Transcription Factors,Neuroscience,Cell Type Marker,Stem Cells,Neural Stem Cells,Oligodendrocyte marker,OLIG2