2700054M22Rik antibody, Nrarp-a antibody, fc89b12 antibody, id:ibd2282 antibody, wu:fa14d10 antibody, wu:fc89b12 antibody, zgc:100826 antibody, Nrarp-b antibody, zgc:101875 antibody, Notch-regulated ankyrin repeat protein antibody, NOTCH regulated ankyrin repeat protein antibody, NOTCH regulated ankyrin repeat protein S homeolog antibody, NOTCH-regulated ankyrin repeat protein antibody, NOTCH regulated ankyrin repeat protein a antibody, NOTCH regulated ankyrin repeat protein b antibody, Nrarp antibody, NRARP antibody, nrarp.S antibody, nrarpa antibody, nrarpb antibody
背景
Downstream effector of Notch signaling. Involved in the regulation of liver cancer cells self-renewal. Involved in angiogenesis acting downstream of Notch at branch points to regulate vascular density. Proposed to integrate endothelial Notch and Wnt signaling to control stalk cell proliferation and to stablilize new endothelial connections during angiogenesis. During somitogenesis involved in maintenance of proper somite segmentation and proper numbers of somites and vertebrae. Required for proper anterior-posterior somite patterning. Proposed to function in a negative feedback loop to destabilize Notch 1 intracellular domain (NICD and downregulate the Notch signal, preventing expansion of the Notch signal into the anterior somite domain (By similarity.,NRARP,Cell Biology & Developmental Biology,Neuroscience,Cardiovascular,Angiogenesis,NRARP