This gene encodes a protein involved in renal tubular development and function. This protein interacts with nephrocystin, and belongs to a multifunctional complex that is localized to actin- and microtubule-based structures. Mutations in this gene are associated with nephronophthisis type 4, a renal disease, and with Senior-Loken syndrome type 4, a combination of nephronophthisis and retinitis pigmentosa. Alternative splicing results in multiple transcript variants.,NPHP4,POC10,SLSN4,Signal Transduction,Cell Biology & Developmental Biology,Cell Cycle,Centrosome,Cell Adhesion,Tight Junctions,Cytoskeleton,NPHP4