MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. Regulatory phosphorylation of the cardiac isoform in vivo by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. Mutations in MYBPC3 are one cause of familial hypertrophic cardiomyopathy.,MYBPC3,CMD1MM,CMH4,FHC,LVNC10,MYBP-C,cardiac,Cell Biology & Developmental Biology,Cytoskeleton,Actins,Cardiovascular,Heart,Contractility,Hypertrophy,MYBPC3