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METTL14 抗体 (AA 1-210)

METTL14 适用: 人 WB, IP, IHC, IF 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6143759
发货至: 中国
  • 抗原 See all METTL14 抗体
    METTL14 (Methyltransferase Like 14 (METTL14))
    抗原表位
    • 15
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-210
    适用
    • 27
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    宿主
    • 26
    • 1
    克隆类型
    • 27
    多克隆
    标记
    • 9
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This METTL14 antibody is un-conjugated
    应用范围
    • 21
    • 13
    • 13
    • 8
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC), Immunofluorescence (IF)
    序列
    MDSRLQEIRE RQKLRRQLLA QQLGAESADS IGAVLNSKDE QREIAETRET CRASYDTSAP NAKRKYLDEG ETDEDKMEEY KDELEMQQDE ENLPYEEEIY KDSSTFLKGT QSLNPHNDYC QHFVDTGHRP QNFIRDVGLA DRFEEYPKLR ELIRLKDELI AKSNTPPMYL QADIEAFDIR ELTPKFDVIL LEPPLEEYYR ETGITANEKC
    交叉反应
    人, 小鼠, 大鼠
    产品特性
    Polyclonal Antibodies
    免疫原
    Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human METTL14 (NP_066012.1).
    亚型
    IgG
  • 应用备注
    WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200,IP,1:50 - 1:200
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Avoid freeze / thaw cycles.
  • Xiang, Yang, Liu, Wu, Chen, Yang: "N6-Methyladenosines Modulate A-to-I RNA Editing." in: Molecular cell, Vol. 69, Issue 1, pp. 126-135.e6, (2018) (PubMed).

    Xiang, Laurent, Hsu, Nachtergaele, Lu, Sheng, Xu, Chen, Ouyang, Wang, Ling, Hsu, Zou, Jambhekar, He, Shi: "RNA m6A methylation regulates the ultraviolet-induced DNA damage response." in: Nature, Vol. 543, Issue 7646, pp. 573-576, (2017) (PubMed).

    Yoon, Ringeling, Vissers, Jacob, Pokrass, Jimenez-Cyrus, Su, Kim, Zhu, Zheng, Kim, Wang, Doré, Jin, Regot, Zhuang, Canzar, He, Ming, Song: "Temporal Control of Mammalian Cortical Neurogenesis by m6A Methylation." in: Cell, Vol. 171, Issue 4, pp. 877-889.e17, (2017) (PubMed).

  • 抗原
    METTL14 (Methyltransferase Like 14 (METTL14))
    别名
    METTL14 (METTL14 产品)
    别名
    RGD1304822 antibody, G430022H21Rik antibody, mKIAA1627 antibody, zgc:77296 antibody, methyltransferase like 14 antibody, methyltransferase like 14 L homeolog antibody, Mettl14 antibody, mettl14.L antibody, METTL14 antibody, mettl14 antibody
    背景
    The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6 position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. N6-methyladenosine (m6A, which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing. M6A acts as a key regulator of mRNA stability by promoting mRNA destabilization and degradation (By similarity. In embryonic stem cells (ESCs, m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization (By similarity. M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis (By similarity. M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells (By similarity.,METTL14,hMETTL14,Cell Biology & Developmental Biology,METTL14
    分子量
    52 kDa
    基因ID
    57721
    UniProt
    Q9HCE5
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