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C6orf150 抗体 (AA 350-522)

C6orf150 适用: 人 WB, IHC, IP, IF 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6143590
发货至: 中国
  • 抗原 See all C6orf150 抗体
    C6orf150 (Chromosome 6 Open Reading Frame 150 (C6orf150))
    抗原表位
    • 7
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 350-522
    适用
    • 29
    • 7
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    宿主
    • 32
    • 1
    克隆类型
    • 32
    • 1
    多克隆
    标记
    • 16
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This C6orf150 antibody is un-conjugated
    应用范围
    • 27
    • 17
    • 7
    • 6
    • 5
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)
    序列
    KQLRLKPFYL VPKHAKEGNG FQEETWRLSF SHIEKEILNN HGKSKTCCEN KEEKCCRKDC LKLMKYLLEQ LKERFKDKKH LDKFSSYHVK TAFFHVCTQN PQDSQWDRKD LGLCFDNCVT YFLQCLRTEK LENYFIPEFN LFSSNLIDKR SKEFLTKQIE YERNNEFPVF DEF
    交叉反应
    人, 小鼠, 大鼠
    产品特性
    Polyclonal Antibodies
    纯化方法
    Affinity purification
    免疫原
    Recombinant fusion protein containing a sequence corresponding to amino acids 350-522 of human cGAS (NP_612450.2).
    亚型
    IgG
    Top Product
    Discover our top product C6orf150 Primary Antibody
  • 应用备注
    WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:100,IP,1:50 - 1:100
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原
    C6orf150 (Chromosome 6 Open Reading Frame 150 (C6orf150))
    别名
    CGAS (C6orf150 产品)
    别名
    C6orf150 antibody, cGAS antibody, h-cGAS antibody, Mab-21 domain containing 1 antibody, cyclic GMP-AMP synthase antibody, MB21D1 antibody, CGAS antibody
    背景
    Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and plays a key role in innate immunity (PubMed:23258413, PubMed:23707061, PubMed:23722159, PubMed:24077100, PubMed:25131990, PubMed:29976794, PubMed:30799039). Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p] (PubMed:28363908, PubMed:28214358). Acts as a key cytosolic DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses (PubMed:28363908). Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production (PubMed:28363908, PubMed:28314590). Preferentially recognizes and binds curved long DNAs (PubMed:30007416). In contrast to other mammals, human CGAS displays species-specific mechanisms of DNA recognition and produces less cyclic GMP-AMP (cGAMP), allowing a more fine-tuned response to pathogens (PubMed:30007416). Has antiviral activity by sensing the presence of dsDNA from DNA viruses in the cytoplasm (PubMed:28363908). Also acts as an innate immune sensor of infection by retroviruses, such as HIV-1, by detecting the presence of reverse-transcribed DNA in the cytosol (PubMed:23929945). Detection of retroviral reverse-transcribed DNA in the cytosol may be indirect and be mediated via interaction with PQBP1, which directly binds reverse-transcribed retroviral DNA (PubMed:26046437). Also detects the presence of DNA from bacteria, such as M.tuberculosis (PubMed:26048138). cGAMP can be transferred from producing cells to neighboring cells through gap junctions, leading to promote TMEM173/STING activation and convey immune response to connecting cells (PubMed:24077100).,MB21D1,C6orf150,cGAS,h-cGAS,CGAS,Cell Biology & Developmental Biology,CGAS
    分子量
    49 kDa/58 kDa
    基因ID
    115004
    UniProt
    Q8N884
    途径
    Activation of Innate immune Response
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