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HSD17B1 抗体 (AA 1-328)

HSD17B1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6142002
发货至: 中国
  • 抗原 See all HSD17B1 抗体
    HSD17B1 (Hydroxysteroid (17-Beta) Dehydrogenase 1 (HSD17B1))
    抗原表位
    • 9
    • 9
    • 6
    • 5
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    AA 1-328
    适用
    • 62
    • 20
    • 20
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    宿主
    • 62
    • 2
    • 1
    克隆类型
    • 63
    • 2
    多克隆
    标记
    • 22
    • 8
    • 5
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This HSD17B1 antibody is un-conjugated
    应用范围
    • 45
    • 24
    • 12
    • 8
    • 7
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
    序列
    MARTVVLITG CSSGIGLHLA VRLASDPSQS FKVYATLRDL KTQGRLWEAA RALACPPGSL ETLQLDVRDS KSVAAARERV TEGRVDVLVC NAGLGLLGPL EALGEDAVAS VLDVNVVGTV RMLQAFLPDM KRRGSGRVLV TGSVGGLMGL PFNDVYCASK FALEGLCESL AVLLLPFGVH LSLIECGPVH TAFMEKVLGS PEEVLDRTDI HTFHRFYQYL AHSKQVFREA AQNPEEVAEV FLTALRAPKP TLRYFTTERF LPLLRMRLDD PSGSNYVTAM HREVFGDVPA KAEAGAEAGG GAGPGAEDEA GRGAVGDPEL GDPPAAPQ
    交叉反应
    人, 小鼠, 大鼠
    产品特性
    Polyclonal Antibodies
    纯化方法
    Affinity purification
    免疫原
    Recombinant fusion protein containing a sequence corresponding to amino acids 1-328 of human HSD17B1 (NP_000404.2).
    亚型
    IgG
    Top Product
    Discover our top product HSD17B1 Primary Antibody
  • 应用备注
    WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原
    HSD17B1 (Hydroxysteroid (17-Beta) Dehydrogenase 1 (HSD17B1))
    别名
    HSD17B1 (HSD17B1 产品)
    别名
    EDH17B2 antibody, EDHB17 antibody, HSD17 antibody, SDR28C1 antibody, 17HSDB1 antibody, 17beta-HSD antibody, E2DH antibody, Hsd17ba antibody, 17BHD1 antibody, zfHSD17B1 antibody, hydroxysteroid 17-beta dehydrogenase 1 antibody, hydroxysteroid (17-beta) dehydrogenase 1 antibody, HSD17B1 antibody, Hsd17b1 antibody, hsd17b1 antibody
    背景
    This gene encodes a member of the 17beta-hydroxysteroid dehydrogenase family of short-chain dehydrogenases/reductases. It has a dual function in estrogen activation and androgen inactivation and plays a major role in establishing the estrogen E2 concentration gradient between serum and peripheral tissues. The encoded protein catalyzes the last step in estrogen activation, using NADPH to convert estrogens E1 and E2 and androgens like 4-androstenedione, to testosterone. It has an N-terminal short-chain dehydrogenase domain with a cofactor binding site, and a narrow, hydrophobic C-terminal domain with a steroid substrate binding site. This gene is expressed primarily in the placenta and ovarian granulosa cells, and to a lesser extent, in the endometrium, adipose tissue, and prostate. Polymorphisms in this gene have been linked to breast and prostate cancer. A pseudogene of this gene has been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016],HSD17B1,17-beta-HSD,20-alpha-HSD,E2DH,EDH17B2,EDHB17,HSD17,SDR28C1,Cancer,Signal Transduction,Cell Biology & Developmental Biology,Growth factor,Endocrine & Metabolism,Neuroscience,HSD17B1
    分子量
    34 kDa
    基因ID
    3292
    UniProt
    P14061
    途径
    Metabolism of Steroid Hormones and Vitamin D, Steroid Hormone Biosynthesis
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