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GP1BB 抗体 (AA 27-147)

GP1BB 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6141287
发货至: 中国
  • 抗原 See all GP1BB 抗体
    GP1BB (Glycoprotein Ib (Platelet), beta Polypeptide (GP1BB))
    抗原表位
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 27-147
    适用
    • 14
    • 10
    • 2
    宿主
    • 16
    • 1
    克隆类型
    • 16
    • 1
    多克隆
    标记
    • 9
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This GP1BB antibody is un-conjugated
    应用范围
    • 9
    • 6
    • 3
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB)
    序列
    PAPCSCAGTL VDCGRRGLTW ASLPTAFPVD TTELVLTGNN LTALPPGLLD ALPALRTAHL GANPWRCDCR LVPLRAWLAG RPERAPYRDL RCVAPPALRG RLLPYLAEDE LRAACAPGPL C
    交叉反应
    人, 小鼠, 大鼠
    产品特性
    Polyclonal Antibodies
    纯化方法
    Affinity purification
    免疫原
    Recombinant fusion protein containing a sequence corresponding to amino acids 27-147 of human GP1BB (NP_000398.1).
    亚型
    IgG
    Top Product
    Discover our top product GP1BB Primary Antibody
  • 应用备注
    WB,1:200 - 1:1000
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原
    GP1BB (Glycoprotein Ib (Platelet), beta Polypeptide (GP1BB))
    别名
    GP1BB (GP1BB 产品)
    别名
    BDPLT1 antibody, BS antibody, CD42C antibody, GPIBB antibody, glycoprotein Ib (platelet), beta polypeptide antibody, glycoprotein Ib platelet beta subunit antibody, glycoprotein Ib, beta polypeptide antibody, GP1BB antibody, Gp1bb antibody
    背景
    Platelet glycoprotein Ib (GPIb) is a heterodimeric transmembrane protein consisting of a disulfide-linked 140 kD alpha chain and 22 kD beta chain. It is part of the GPIb-V-IX system that constitutes the receptor for von Willebrand factor (VWF), and mediates platelet adhesion in the arterial circulation. GPIb alpha chain provides the VWF binding site, and GPIb beta contributes to surface expression of the receptor and participates in transmembrane signaling through phosphorylation of its intracellular domain. Mutations in the GPIb beta subunit have been associated with Bernard-Soulier syndrome, velocardiofacial syndrome and giant platelet disorder. The 206 amino acid precursor of GPIb beta is synthesized from a 1.0 kb mRNA expressed in plateletes and megakaryocytes. A 411 amino acid protein arising from a longer, unspliced transcript in endothelial cells has been described, however, the authenticity of this product has been questioned. Yet another less abundant GPIb beta mRNA species of 3.5 kb, expressed in nonhematopoietic tissues such as endothelium, brain and heart, was shown to result from inefficient usage of a non-consensus polyA signal in the neighboring upstream gene (SEPT5, septin 5). In the absence of polyadenylation from its own imperfect site, the SEPT5 gene produces read-through transcripts that use the consensus polyA signal of this gene.,GP1BB,BDPLT1,BS,CD42C,GPIBB,GPIbbeta,Immunology & Inflammation,CD markers,GP1BB
    分子量
    21 kDa/43 kDa
    基因ID
    2812
    UniProt
    P13224
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