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- 抗原 See all Cullin 2 (CUL2) 抗体
- Cullin 2 (CUL2)
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抗原表位
- AA 40-310
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Cullin 2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF)
- 序列
- LEYVERATWN DRFSDIYALC VAYPEPLGER LYTETKIFLE NHVRHLHKRV LESEEQVLVM YHRYWEEYSK GADYMDCLYR YLNTQFIKKN KLTEADLQYG YGGVDMNEPL MEIGELALDM WRKLMVEPLQ AILIRMLLRE IKNDRGGEDP NQKVIHGVIN SFVHVEQYKK KFPLKFYQEI FESPFLTETG EYYKQEASNL LQESNCSQYM EKVLGRLKDE EIRCRKYLHP SSYTKVIHEC QQRMVADHLQ FLHAECHNII RQEKKNDMAN M
- 交叉反应
- 人
- 产品特性
- Polyclonal Antibodies
- 纯化方法
- Affinity purification
- 免疫原
- Recombinant fusion protein containing a sequence corresponding to amino acids 40-310 of human Cullin 2 (NP_001185708.1).
- 亚型
- IgG
- Top Product
- Discover our top product CUL2 Primary Antibody
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anti-Cullin 2 (CUL2) (C-Term) antibody
CUL2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cullin 2 (CUL2) (C-Term) antibodyCUL2 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Cullin 2 (CUL2) (AA 591-742) antibodyCUL2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cullin 2 (CUL2) (AA 1-100) antibodyCUL2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Cullin 2 (CUL2) antibodyCUL2 适用: 人, 小鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Cullin 2 (CUL2) (C-Term) antibodyCUL2 适用: 人, 小鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Cullin 2 (CUL2) (AA 1-100) antibodyCUL2 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 4G11 unconjugated
anti-Cullin 2 (CUL2) (C-Term) antibodyVerified CUL2 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Cullin 2 (CUL2) (AA 264-280), (Middle Region) antibodyCUL2 适用: 人, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Cullin 2 (CUL2) (C-Term) antibodyCUL2 适用: 人, 小鼠, 大鼠, 犬, Cow, 小鸡, Pig WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB,1:500 - 1:2000,IF,1:50 - 1:200
- 说明
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HIGH QUALITY
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- 抗原
- Cullin 2 (CUL2)
- 别名
- CUL2 (CUL2 产品)
- 别名
- cul2 antibody, Cullin-2 antibody, fj48a06 antibody, wu:fj48a06 antibody, cullin-2 antibody, LOC100221330 antibody, 1300003D18Rik antibody, 4932411N15Rik antibody, AI327301 antibody, mKIAA4106 antibody, ATCUL2 antibody, F22D16.2 antibody, F22D16_2 antibody, cullin 2 antibody, cullin 2 antibody, cullin-2 antibody, putative cullin-2 (cul-2) antibody, cullin 2 L homeolog antibody, Cullin-2 antibody, cul2 antibody, CUL2 antibody, PTRG_05231 antibody, Smp_079740 antibody, LOC100550749 antibody, Cul2 antibody, cul2.L antibody, cul-2 antibody
- 背景
- Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. CUL2 may serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL mediates the ubiquitination of hypoxia-inducible factor (HIF. A number of ECS complexes (containing either KLHDC2, KLHDC3, KLHDC10, APPBP2, FEM1A, FEM1B or FEM1C as substrate-recognition component are part of the DesCEND (destruction via C-end degrons pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins.,CUL2,cullin-2,Cancer,Cell Biology & Developmental Biology,Apoptosis,Cell Cycle,Cell cycle inhibitors,Ubiquitin,Ubiquitin-Proteasome Signaling Pathway,CUL2
- 分子量
- 86 kDa/89 kDa
- 基因ID
- 8453
- UniProt
- Q13617
- 途径
- M Phase, Asymmetric Protein Localization, SARS-CoV-2 Protein Interactome
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