This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Loss of the related gene in mouse results in a shortened circadian cycle in complete darkness.,CRY1,PHLL1,DSPD,Signal Transduction,G protein signaling,G-Protein-Coupled Receptors(GPCR),Neuroscience,Cardiovascular,Blood,Blood Pressure regulation,CRY1