This gene encodes a protein that belongs to a family of helicases that are involved in the ATP-dependent unwinding of nucleic acid duplexes. The encoded protein is the largest subunit of the activating signal cointegrator 1 complex that is involved in DNA repair and resistance to alkylation damage. Alternate splicing results in multiple transcript variants.,ASCC3,ASC1p200,HELIC1,RNAH,Epigenetics & Nuclear Signaling,Cell Biology & Developmental Biology,Hippo Signaling Pathway,ASCC3