This gene encodes a protein that binds actin and calcium. This gene is induced by cytokines and interferon and may promote macrophage activation and growth of vascular smooth muscle cells and T-lymphocytes. Polymorphisms in this gene may be associated with systemic sclerosis. Alternative splicing results in multiple transcript variants, but the full-length and coding nature of some of these variants is not certain.,AIF1,AIF-1,IBA1,IRT-1,IRT1,Iba1,Cell Biology & Developmental Biology,Cell Cycle,Cell cycle inhibitors,Endocrine & Metabolism,Immunology & Inflammation,Cell Intrinsic Innate Immunity Signaling Pathway,Neuroscience,Cell Type Marker,Microglia marker,AIF1