Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
特异性
NOL5A,NOP56,NOP56 ribonucleoprotein,NOP56 ribonucleoprotein homolog (yeast),NOP56 ribonucleoprotein homolog,Nucleolar protein 56,Nucleolar protein 5A (56kD with KKE/D repeat),Nucleolar protein 5A,Nucleolar protein Nop56,RP4-686C3.1,SCA36
NOP56 (NOP56 Ribonucleoprotein) is a Protein Coding gene. Diseases associated with NOP56 include Spinocerebellar Ataxia 36 and Spinocerebellar Ataxia Type36. Among its related pathways are Chaperonin-mediated protein folding and rRNA processing in the nucleus and cytosol. GO annotations related to this gene include poly(A) RNA binding and snoRNA binding.Nop56p is a yeast nucleolar protein that is part of a complex with the nucleolar proteins Nop58p and fibrillarin. Nop56p is required for assembly of the 60S ribosomal subunit and is involved in pre-rRNA processing. The protein encoded by this gene is similar in sequence to Nop56p and is also found in the nucleolus. Expansion of a GGCCTG repeat from 3-8 copies to 1500-2500 copies in an intron of this gene results in spinocerebellar ataxia 36. Multiple transcript variants encoding several different isoforms have been found for this gene, but the full-length nature of most of them has not been determined.