GG2 1,Head and neck tumor and metastasis-related protein,MDC-3.13,NDED,NF-kappa-B-inducible DED-containing protein,SCC S2,SCC-S2,SCCS2,TFIP8,TNF alpha-induced protein 8,TNF induced protein,TNF-induced protein GG2-1,TNFAIP 8,TNFAIP8,Tumor necrosis factor alpha induced protein 8,Tumor necrosis factor alpha-induced protein 8
Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation.