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- 抗原
- ABCE1 (RLI1) (ABC Transporter E Family Member 1 (RLI1))
- 适用
- 人, 小鼠, 大鼠
- 宿主
- 兔
- 克隆类型
- 多克隆
- 应用范围
- Western Blotting (WB)
- 纯化方法
- Antigen affinity purified
- 免疫原
- Amino acids K419-D599 from the human protein were used as the immunogen for the ABCE1 antibody.
- 亚型
- IgG
-
- 应用备注
- Western blot: 0.5-1 μg/mL
- 限制
- 仅限研究用
-
- 缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
- 储存条件
- -20 °C
- 储存方法
- After reconstitution, the ABCE1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
-
- 抗原
- ABCE1 (RLI1) (ABC Transporter E Family Member 1 (RLI1))
- 别名
- ABCE1 / ATP binding cassette E1
- 别名
- ATRLI1 antibody, RNAse l inhibitor protein 1 antibody, RNAse l inhibitor protein 1 antibody, ABCE1 antibody
- 背景
- ATP binding cassette E1 (ABCE1, also RNase L inhibitor) is an ATPase found in humans involved in viral assembly. It is a member of the ATP-binding cassette (ABC) transporters superfamily and OABP subfamily. ABCE1 inhibits the action of ribonuclease L. Ribonuclease L normally binds to 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) and inhibits the interferon-regulated 2-5A/RNase L pathway, which is used by viruses. ABCE1 heterodimerize with ribonuclease L and prevents its interaction with 2-5A, antagonizing the anti-viral properties of ribonuclease L, and allow the virus to synthesize viral proteins. It has also been implicated to have an effect in tumorcell proliferation and antiapoptosis.
- UniProt
- P61221
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