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IDE 抗体

IDE 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), FACS 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN5708390
发货至: 中国
  • 抗原 See all IDE 抗体
    IDE (Insulin-Degrading Enzyme (IDE))
    适用
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    人, 小鼠, 大鼠
    宿主
    • 61
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    克隆类型
    • 66
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    多克隆
    标记
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    This IDE antibody is un-conjugated
    应用范围
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    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)
    纯化方法
    Antigen affinity purified
    免疫原
    A recombinant human protein corresponding to amino acids F485-K756 was used as the immunogen for the IDE antibody.
    亚型
    IgG
    Top Product
    Discover our top product IDE Primary Antibody
  • 应用备注
    Optimal dilution of the IDE antibody should be determined by the researcher.\. Western blot: 0.1-0.5 μg/mL, IHC (FFPE): 0.5-1 μg/mL,FACS: 1-3 μg/10^6 cells, Direct ELISA: 0.1-0.5 μg/mL
    限制
    仅限研究用
  • 缓冲液
    0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
    储存条件
    -20 °C
    储存方法
    After reconstitution, the IDE antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
  • 抗原
    IDE (Insulin-Degrading Enzyme (IDE))
    别名
    IDE / Insulin degrading enzyme (IDE 产品)
    别名
    zgc:162603 antibody, IDE antibody, 1300012G03Rik antibody, 4833415K22Rik antibody, AA675336 antibody, AI507533 antibody, INSDEGM antibody, INSULYSIN antibody, insulin degrading enzyme antibody, insulin-degrading enzyme antibody, metallopeptidase antibody, IDE antibody, ide antibody, LOC591315 antibody, CC1G_01115 antibody, Bm1_26615 antibody, PTRG_10875 antibody, SJAG_01430 antibody, EBI_21700 antibody, VDBG_06702 antibody, LOAG_08082 antibody, PGTG_04982 antibody, Tsp_00424 antibody, Ide antibody
    背景
    Insulin-degrading enzyme, also known as IDE, is an enzyme. This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
    UniProt
    P14735
    途径
    SARS-CoV-2 Protein Interactome
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