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CLIP 抗体 (AA 25-39)

CLIP 适用: 人, 大鼠, 小鼠 IHC (p) 宿主: 兔 Monoclonal CLIP-2040R unconjugated
产品编号 ABIN5707527
发货至: 中国
  • 抗原 See all CLIP products
    CLIP (Corticotropin-Like Intermediate Peptide (CLIP))
    抗原表位
    • 3
    • 2
    • 2
    AA 25-39
    适用
    人, 大鼠, 小鼠
    宿主
    • 7
    • 4
    克隆类型
    • 8
    • 3
    单克隆
    标记
    • 9
    • 1
    • 1
    This CLIP antibody is un-conjugated
    应用范围
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    纯化方法
    Purified
    纯度
    Protein A affinity chromatography
    免疫原
    Amino acids 25-39 (NGAEDESAEAFPLEF) of Adrenocorticotropic hormone (CLIP sequence) were used as the immunogen for this ACTH antibody.
    克隆位点
    CLIP-2040R
    亚型
    IgG kappa
  • 应用备注
    The optimal dilution of the recombinant ACTH antibody for each application should be determined by the researcher.

    1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. Immunohistochemistry (FFPE): 0.5-1 μg/mL for 30 min at RT,Prediluted IHC only format : incubate for 30 min at RT (1)
    限制
    仅限研究用
  • 缓冲液
    1 mg/mL in 1X PBS, BSA free, sodium azide free
    储存液
    Azide free
    储存条件
    4 °C,-20 °C
    储存方法
    Store the recombinant ACTH antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
  • 抗原
    CLIP (Corticotropin-Like Intermediate Peptide (CLIP))
    别名
    ACTH / CLIP (CLIP 产品)
    背景
    ACTH (same as Corticotropin) is a 39 amino acid active peptide produced by the anterior pituitary. This mAb is specific to CLIP (aa 17-39 of ACTH) and does not react with Synacthen (aa 1-24 of ACTH). POMC (pro-opiomelanocortin or corticotropin-lipotropin) is a 267 amino acid polypeptide hormone precursor that goes through extensive, tissue-specific posttranslational processing by convertases. POMC is cleaved into ten hormone chains named NPP, ACTH, alpha-MSH (Melanocyte Stimulating Hormone), beta-MSH, gamma-MSH, CLIP (corticotropin-like intermediary peptide), Lipotropin-beta, Lipotropin-gamma, beta-endorphin and Met-enkephalin. ACTH is also produced by cells of immune system (T-cells, B-cells, and macrophages) in response to stimuli associated with stress. Anti-ACTH is a useful marker in classification of pituitary tumors and the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs). It also may react with other tumors (e.g. some small cell carcinomas of the lung) causing paraneoplastic syndromes by secreting ACTH.
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