BRD7 抗体
-
- 抗原 See all BRD7 抗体
- BRD7 (Bromodomain Containing 7 (BRD7))
-
适用
- 人, 小鼠, 大鼠
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- This BRD7 antibody is un-conjugated
-
应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- 免疫原
- bromodomain containing 7
- 亚型
- IgG
- Top Product
- Discover our top product BRD7 Primary Antibody
-
-
- 应用备注
- Optimal working dilution should be determined by the investigator.
- 说明
-
HeLa cells were subjected to SDS PAGE followed by western blot with FNab00948(BRD7 antibody) at dilution of 1:500
- 限制
- 仅限研究用
-
- 缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze / thaw cycles.
- 储存条件
- -20 °C
- 有效期
- 12 months
-
- 抗原
- BRD7 (Bromodomain Containing 7 (BRD7))
- 别名
- BRD7 (BRD7 产品)
- 别名
- zgc:66347 antibody, wu:fc95f02 antibody, MGC79478 antibody, BRD7 antibody, BP75 antibody, CELTIX1 antibody, NAG4 antibody, Ptpn13ip antibody, bromodomain containing 7 L homeolog antibody, bromodomain containing 7 antibody, brd7.L antibody, brd7 antibody, BRD7 antibody, Brd7 antibody
- 背景
- Synonyms:BP75, CELTIX1 Background:Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR(By similarity). Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9'(H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase.
- 分子量
- 70-74 kDa
- 基因ID
- 29117
- UniProt
- Q9NPI1
-