Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser234 of rabphilin 3A.
应用备注
The antibody has been directly tested for reactivity in Western blots with rat tissue. It is anticipated that the antibody will react with mouse based on the fact that this species has 100 % homology with the amino acid sequence used as antigen.
限制
仅限研究用
状态
Liquid
缓冲液
100 μLin 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg per mL BSA and 50 % glycerol.
储存条件
-20 °C
储存方法
Rabphilin antibody can be stored at -20°C and is stable at -20°C for at least 1 year.
抗原
Rabphilin (RPH)
别名
Rabphilin
背景
Rabphilin-3A is a peripheral membrane protein that binds Ca2+ and phospholipids and is attached to synaptic vesicle membranes (Geppert et al., 1994,Li et al., 1994). The expression of rabphilin 3A is reduced in an animal model of Huntington's disease(Smith et al., 2005). Rabphilin can be phosphorylated at Ser234 by both CAM kinase II and PKA and this phosphorylation has been suggested to regulate neuronal activity during development in a synapse-specific manner (Fykse et al., 1995,Foletti and Scheller, 2001).