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Cyclin E1 抗体

CCNE1 适用: 人 WB, IF, FACS, IHC (p) 宿主: 小鼠 Monoclonal HE12 unconjugated
产品编号 ABIN567783
发货至: 中国
  • 抗原 See all Cyclin E1 (CCNE1) 抗体
    Cyclin E1 (CCNE1)
    适用
    • 147
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    宿主
    • 123
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    小鼠
    克隆类型
    • 114
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    单克隆
    标记
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    This Cyclin E1 antibody is un-conjugated
    应用范围
    • 97
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    Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    特异性
    This antibody reacts with Cyclin E (50 kDa) on Western blotting. This monoclonal antibody may nonspecifically react with macrophages, endothelial cells and some stromal cells in Immunohistochemistry.
    纯化方法
    Protein-A Agarose Chromatography of hybridoma supernatant.
    免疫原
    Human recombinant full length His-Cyclin E.
    克隆位点
    HE12
    亚型
    IgG1
    Top Product
    Discover our top product CCNE1 Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 浓度
    1.0 mg/mL
    缓冲液
    PBS, pH 7.2 containing 50 % Glycerol without preservatives.
    储存液
    Without preservative
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    -20 °C
    储存方法
    Store the antibody (in aliquots) at -20 °C.
  • 抗原
    Cyclin E1 (CCNE1)
    别名
    Cyclin E1 (CCNE1 产品)
    背景
    Cyclin E, a positive regulator of the cell cycle, controls the transition of cells from G1 to S phase. Cyclin E forms a complex with Cdk2, the active kinase follows cyclin D/Cdk4 in progressively phosphorylating pRb, releasing it from members of the E2F family. E2F transcrIPPtion factors in turn activate a set of target genes that are essential for entry into S phase. Deregulation of the G1-S checkpoint contributes to uncontrolled cell division, a hallmark of cancer. Cyclin E overexpression and deregulation have been shown in several cancers including breast, colorectal, gastric and lungSynonyms: CCNE, CCNE1, Cyclin-E1
    基因ID
    898
    NCBI登录号
    NP_001229
    UniProt
    P24864
    途径
    Cell Division Cycle, Intracellular Steroid Hormone Receptor Signaling Pathway, Nuclear Hormone Receptor Binding, Mitotic G1-G1/S Phases
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