Recombinant ITGA5 (Volociximab Biosimilar) 抗体
适用: 人
IHC, BR, ELISA, FACS, IF
宿主: Human
Monoclonal
M200
unconjugated
Recombinant Antibody
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- 抗原
- ITGA5 (Volociximab Biosimilar)
- 抗体类型
- Recombinant Antibody
- 适用
- 人
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宿主
-
Human
-
克隆类型
- 单克隆
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标记
- 非结合性
- 应用范围
- Immunohistochemistry (IHC), Blocking Reagent (BR), ELISA, Flow Cytometry (FACS), Immunofluorescence (IF)
- 特异性
- The antibody binds to human α5β1 integrin with a Kd of 0.367 nM (determined by Biacore), an EC50 of 0.2 nM and an IC50 of 2.3 nM.
- 产品特性
-
OriginalSpeciesName: Human
OriginalFormat: IgG4
- 纯化方法
- Purified antibody.
- 纯度
- > 98 % as determined by SDS-PAGE
- 内毒素水平
- Endotoxin is < 1.0 EU/mg as determined by the LAL method
- 免疫原
- Heterodimeric alpha5beta1Fc fusion protein
- 克隆位点
- M200
- 亚型
- IgG4 kappa
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anti-ITGA5 (Volociximab Biosimilar) antibody
适用: 人 IHC, BR, ELISA, FACS, IF 宿主: 兔 Monoclonal M200 unconjugated Recombinant Antibody
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- 应用备注
- The antibody binds specifically to a5ß1 integrin, which is part of the superfamily of glycoprotein transmembrane receptors for ligands such as fibronectin, vitronectin, laminins and collagens. The a5ß1 integrin receptor plays a key role in cellular processes such as inflammation, cell proliferation, angiogenesis and tumour metastasis. Comprising the variable domain of the original mouse antibody, a chimeric mouse:human IgG4 version of this antibody has been tested in vivo: In cynomolgus monkeys with laser-induced choroidal neovascularization (CNV), in rabbit models and in human volunteers. The antibody reached Phase II clinical trials with PDL Biopharma and Biogen-Idec.
- 说明
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NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar.
- 限制
- 仅限研究用
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- 缓冲液
- PBS with 0.02 % Proclin 300.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- 抗原
- ITGA5 (Volociximab Biosimilar)
- 别名
- CD49e antibody, FNRA antibody, VLA5A antibody, integrin subunit alpha 5 antibody, ITGA5 antibody
- 物质类
- Biosimilar
- 背景
- Fibronectin receptor, CD49 antigen-like family member E, Integrin alpha-F, VLA-5, CD49e.
- UniProt
- P08648
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