Recombinant CD4 (Clenoliximab Biosimilar) 抗体
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- 抗原
- CD4 (Clenoliximab Biosimilar)
- 抗体类型
- Recombinant Antibody
- 适用
- 人, Chimpanzee
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宿主
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Human
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克隆类型
- 单克隆
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标记
- 非结合性
- 应用范围
- Surface Plasmon Resonance (SPR), Blocking Reagent (BR), ELISA, Flow Cytometry (FACS), Immunohistochemistry (IHC)
- 原理
- Anti-CD4 [CE9.1 (Clenoliximab)], Human IgG4, lambda
- 特异性
- The antibody binds to human CD4 with a Kd of 1.0 nM and an ED50 of 0.2 μg/mL.
- 交叉反应
- Chimpanzee
- 产品特性
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Original Species of Ab: Human
Original Format of Ab: IgG4 (primatized)
- 纯化方法
- Protein A affinity purified
- 纯度
- > 98 % as determined by SDS-PAGE
- 内毒素水平
- Endotoxin is < 1.0 EU/mg as determined by the LAL method
- 免疫原
- Domain 1 of human CD4.
- 克隆位点
- CE9-1
- 亚型
- IgG4 lambda
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anti-CD4 (Clenoliximab Biosimilar) antibody
适用: 人, Chimpanzee SPR, BR, ELISA, FACS, IHC 宿主: 兔 Chimeric CE9-1 unconjugated Recombinant Antibody
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- 应用备注
- The antibody binds specifically to CD4, a molecule which is part of the immunolgobulin super-family, expressed on the surface of helper T cells. The CD4 Molecule acts as a co-receptor in the activation of T cells, aiding the interaction between the TCR and MHC II of the antigen-presenting cell. The antibody is classified as "primatized", as the variable regions of the light and heavy chains are obtained from primates, while the lamda light chain and γ4 heavy chain constant domains are human. The antibody was engineered from the primatized IgG1 monoclonal antibody Keliximab by substituting two key residues. The role of the antibody as an immunosuppressor has been tested in vivo, by intravenous administration in chimpanzees and human volunteers. The antibody reached Phase II clinical trials with Biogen-Idec.
- 说明
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NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar. This reformatted human antibody was made using the variable domain sequences of the original Human IgG4 (primatized) format, for improved compatibility with existing reagents, assays and techniques.
- 限制
- 仅限研究用
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- 浓度
- 1 mg/mL
- 缓冲液
- PBS with 0.02 % Proclin 300.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- 抗原
- CD4 (Clenoliximab Biosimilar)
- 物质类
- Biosimilar
- 背景
- P55, T cell surface antign T4/Leu-3.
- UniProt
- P01730
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