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Recombinant RSV (Felvizumab Biosimilar) 抗体

适用: Respiratory Syncytial Virus (RSV) ELISA, Func 宿主: 兔 Monoclonal RSHZ19 unconjugated Recombinant Antibody
产品编号 ABIN5668207
发货至: 中国
  • 抗原 See all RSV (Felvizumab Biosimilar) products
    RSV (Felvizumab Biosimilar)
    抗体类型
    Recombinant Antibody
    适用
    Respiratory Syncytial Virus (RSV)
    宿主
    • 1
    克隆类型
    • 1
    单克隆
    标记
    • 1
    This RSV (Felvizumab Biosimilar) antibody is un-conjugated
    应用范围
    ELISA, Functional Studies (Func)
    特异性
    This antibody is specific for the conserved fusion (F) protein of RSV.
    产品特性

    OriginalSpeciesName: Human

    OriginalFormat: IgG1

    纯化方法
    Purified antibody.
    纯度
    > 98 % as determined by SDS-PAGE
    内毒素水平
    Endotoxin is < 1.0 EU/mg as determined by the LAL method
    免疫原
    This antibody was prepared by the humanization of an F protein-specific murine MAb, RSV19. More specifically, molecular techniques were used to insert the complementarity determining regions from murine RSV19 into a human IgG1 heavy and k light chain-variable domain framework.
    克隆位点
    RSHZ19
    亚型
    IgG kappa
  • 应用备注
    Though shown to be safe and well-tolerated (Everitt, 1996) and protective against RSV infection in BALB/c mice and cotton rats (Wyde, 1995), this antibody did not demonstrate efficacy in a Phase 3 study (Reichert, 2008). In in vitro studies, palivizumab, another humanized Mab specific for the F protein of RSV, was 4 to 5-fold more potent than felvizumab in neutralising RSV (Scott, 1999).
    说明

    This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.

    限制
    仅限研究用
  • 缓冲液
    PBS with 0.02 % Proclin 300.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
  • 抗原
    RSV (Felvizumab Biosimilar)
    Abstract
    RSV (Felvizumab Biosimilar) 产品
    物质类
    Biosimilar
    背景
    SB 209763, respiratory syncytial virus
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