MGC83682 antibody, JNKBP-1 antibody, 2810483F24Rik antibody, AW123212 antibody, Jnkbp1 antibody, mKIAA0596 antibody, mitogen-activated protein kinase binding protein 1 L homeolog antibody, mitogen-activated protein kinase binding protein 1 antibody, mitogen activated protein kinase binding protein 1 antibody, mapkbp1.L antibody, MAPKBP1 antibody, Mapkbp1 antibody
背景
This gene encodes a scaffold protein that regulates the JNK (c-Jun N-terminal kinase) and NOD2 (nucleotide-binding oligomerization domain-containing protein 2) signaling pathways. The encoded protein interacts with another related JNK pathway scaffold protein, WDR62, via a conserved dimerization domain, and enhances JNK signaling. This protein may play a role in bacterial immunity by binding to the NOD2 receptor and negatively regulating downstream antibacterial and pro-inflammatory signaling. Mutations in this gene that impair cellular localization of the encoded protein cause a form of nephronophthisis, an autosomal-recessive kidney disorder, in human patients.,MAPKBP1,JNKBP-1,JNKBP1,NPHP20,Signal Transduction,Kinase,MAPKBP1