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TDP1 抗体 (AA 1-608)

TDP1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
产品编号 ABIN565920
发货至: 中国
  • 抗原 See all TDP1 抗体
    TDP1 (Tyrosyl-DNA Phosphodiesterase 1 (TDP1))
    抗原表位
    • 7
    • 7
    • 7
    • 6
    • 6
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-608
    适用
    • 41
    • 15
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    宿主
    • 35
    • 6
    • 1
    小鼠
    克隆类型
    • 37
    • 5
    多克隆
    标记
    • 28
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    This TDP1 antibody is un-conjugated
    应用范围
    • 35
    • 21
    • 10
    • 7
    • 7
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA
    原理
    Mouse polyclonal antibody raised against a full-length recombinant TDP1.
    序列
    MSQEGDYGRW TISSSDESEE EKPKPDKPST SSLLCARQGA ANEPRYTCSE AQKAAHKRKI SPVKFSNTDS VLPPKRQKSG SQEDLGWCLS SSDDELQPEM PQKQAEKVVI KKEKDISAPN DGTAQRTENH GAPACHRLKE EEDEYETSGE GQDIWDMLDK GNPFQFYLTR VSGVKPKYNS GALHIKDILS PLFGTLVSSA QFNYCFDVDW LVKQYPPEFR KKPILLVHGD KREAKAHLHA QAKPYENISL CQAKLDIAFG THHTKMMLLL YEEGLRVVIH TSNLIHADWH QKTQGIWLSP LYPRIADGTH KSGESPTHFK ADLISYLMAY NAPSLKEWID VIHKHDLSET NVYLIGSTPG RFQGSQKDNW GHFRLKKLLK DHASSMPNAE SWPVVGQFSS VGSLGADESK WLCSEFKESM LTLGKESKTP GKSSVPLYLI YPSVENVRTS LEGYPAGGSL PYSIQTAEKQ NWLHSYFHKW SAETSGRSNA MPHIKTYMRP SPDFSKIAWF LVTSANLSKA AWGALEKNGT QLMIRSYELG VLFLPSAFGL DSFKVKQKFF AGSQEPMATF PVPYDLPPEL YGSKDRPWIW NIPYVKAPDT HGNMWVPS
    交叉反应
    产品特性
    Antibody Reactive Against Recombinant Protein.
    免疫原
    TDP1 (AAH15474.1, 1 a.a. ~ 608 a.a) full-length recombinant protein with GST tag.
    Top Product
    Discover our top product TDP1 Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    50 % glycerol
    注意事项
    Aliquot to avoid repeated freezing and thawing.
    储存条件
    -20 °C
    储存方法
    Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
  • Das, Huang, Murai, Rehman, Amé, Sengupta, Das, Majumdar, Zhang, Biard, Majumder, Schreiber, Pommier: "PARP1-TDP1 coupling for the repair of topoisomerase I-induced DNA damage." in: Nucleic acids research, Vol. 42, Issue 7, pp. 4435-49, (2014) (PubMed).

    Katyal, Lee, Nitiss, Downing, Li, Shimada, Zhao, Russell, Petrini, Nitiss, McKinnon: "Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes." in: Nature neuroscience, Vol. 17, Issue 6, pp. 813-21, (2014) (PubMed).

    Hawkins, Subler, Akopiants, Wiley, Taylor, Rice, Windle, Valerie, Povirk: "In vitro complementation of Tdp1 deficiency indicates a stabilized enzyme-DNA adduct from tyrosyl but not glycolate lesions as a consequence of the SCAN1 mutation." in: DNA repair, Vol. 8, Issue 5, pp. 654-63, (2009) (PubMed).

    Das, Antony, Gupta, Dexheimer, Redon, Garfield, Shiloh, Pommier: "Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK." in: The EMBO journal, Vol. 28, Issue 23, pp. 3667-80, (2009) (PubMed).

    Katyal, el-Khamisy, Russell, Li, Ju, Caldecott, McKinnon: "TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo." in: The EMBO journal, Vol. 26, Issue 22, pp. 4720-31, (2007) (PubMed).

  • 抗原
    TDP1 (Tyrosyl-DNA Phosphodiesterase 1 (TDP1))
    别名
    TDP1 (TDP1 产品)
    别名
    2810481F14Rik antibody, 4921509N21Rik antibody, AI838772 antibody, AW493413 antibody, E430034L06Rik antibody, MLZ-501 antibody, SCAN1 antibody, tdp1 antibody, MGC83708 antibody, TDP1 antibody, F8M21.60 antibody, F8M21_60 antibody, tyrosyl-DNA phosphodiesterase 1 antibody, tyrosyl-DNA phosphodiesterase 1 antibody, tyrosyl-DNA Phosphodiesterase (Tdp1) antibody, tyrosyl-DNA phosphodiesterase 1 L homeolog antibody, tyrosyl-DNA phosphodiesterase-like protein antibody, TDP1 antibody, Tc00.1047053511191.10 antibody, Tdp1 antibody, tdp1.L antibody, tdp1 antibody, PTRG_11198 antibody, MCYG_02121 antibody, MGYG_03035 antibody
    背景
    Full Gene Name: tyrosyl-DNA phosphodiesterase 1
    Synonyms: FLJ11090,MGC104252
    基因ID
    55775
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