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SNCA 抗体 (pSer129) (Atto 390)

Name: SNCA 抗体 (pSer129) (Atto 390)
Brand: antibodies-online
SKU: ABIN5650938
Availability: OutOfStock

SNCA 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal Atto 390

Western blot analysis of Human, Mouse brain lysate showing detection of ~16 kDa Alpha Synuclein pSer129 protein using Rabbit Anti-Alpha Synuclein pSer129 Polyclonal Antibody (ABIN5650938). (SNCA 抗体 (pSer129) (Atto 390))

Immunohistochemistry analysis using Rabbit Anti-Alpha Synuclein (pSer129) Polyclonal Antibody (ABIN5650938). (SNCA 抗体 (pSer129) (Atto 390))

IHC

Phospho serine 129 antibody (ABIN5650938) was used to detect phosphorylated alpha synuclein in primary mouse hippocampal neurons treated with 100 nM sonicated mouse alpha synuclein PFFs (ABIN5651245) (A). (SNCA 抗体 (pSer129) (Atto 390))

ICC

Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-Alpha Synuclein pSer129 Polyclonal Antibody (ABIN5650938). (SNCA 抗体 (pSer129) (Atto 390))

ICC

IHC

5 images

产品编号 ABIN5650938

发货至: 中国

Datasheet as PDF

抗原 See all SNCA 抗体

SNCA (Synuclein, alpha (SNCA))
抗原表位
68

28

28

17

16

15

14

10

10

5

4

4

4

4

4

3

3

3

3

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 40-140, pSer129
适用
292

188

187

14

10

10

9

7

7

5

2

2

1

1

1
人, 大鼠, 小鼠
宿主
227

103

5

3

1

1
兔
Compatible Secondaries
克隆类型
216

125
多克隆
标记
145

24

22

16

11

8

8

7

7

6

5

5

5

5

5

5

5

5

5

5

5

5

5

5

5

5

5

2
This SNCA antibody is conjugated to Atto 390
应用范围
224

164

109

71

68

65

56

52

48

41

23

18

10

8

7

2

2

2

1

1

1
Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

特异性

Binds to phosphorylated serine 129 on alpha synuclein. Does not detect unphosphorylated serine 129 alpha synuclein. Detects bands at 100, 75, 45, 15 kDa. Bands above 15 kDa are oligomers.

纯化方法

Peptide Affinity Purified

免疫原

Synthetic peptide of Human Alpha Synuclein pSer129 (40-140 aa), conjugated to Keyhole Limpet Haemocyanin (KLH).

Top Product

Discover our top product SNCA Primary Antibody
anti-Synuclein, alpha (SNCA) (pSer129) antibody
SNCA 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Synuclein, alpha (SNCA) (AA 40-140), (pSer129) antibody (Atto 488)
SNCA 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal Atto 488

anti-Synuclein, alpha (SNCA) (AA 124-134), (pSer129) antibody
SNCA 适用: 人 WB, ELISA, IHC, ICC 宿主: 兔 Monoclonal J18 unconjugated

anti-Synuclein, alpha (SNCA) (AA 124-134), (pSer129) antibody (HRP)
SNCA 适用: 人 WB, ELISA, IHC, ICC 宿主: 兔 Monoclonal J18 HRP

anti-Synuclein, alpha (SNCA) (AA 124-134), (pSer129) antibody (FITC)
SNCA 适用: 人 WB, ELISA, IHC, ICC 宿主: 兔 Monoclonal J18 FITC

anti-Synuclein, alpha (SNCA) (AA 124-134), (pSer129) antibody (PE)
SNCA 适用: 人 WB, ELISA, IHC, ICC 宿主: 兔 Monoclonal J18 PE

anti-Synuclein, alpha (SNCA) (AA 61-140) antibody
SNCA 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated

anti-Synuclein, alpha (SNCA) (AA 40-140), (pSer129) antibody
SNCA 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Synuclein, alpha (SNCA) (AA 40-140), (pSer129) antibody (HRP)
SNCA 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal HRP

anti-Synuclein, alpha (SNCA) (AA 40-140), (pSer129) antibody (FITC)
SNCA 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal FITC

应用备注
- WB (1:1000)
- ICC/IF (1:500)
- optimal dilutions for assays should be determined by the user.
说明

A 1:1000 dilution of ABIN5650938 was sufficient for detection of Alpha Synuclein pSer129 in 15 μg of human brain cell lysates by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.

限制

仅限研究用
状态

Liquid

浓度

0.5 mg/mL

缓冲液

PBS pH 7.4, 50 % glycerol, 0.09 % Sodium Azide

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

-20 °C
抗原

SNCA (Synuclein, alpha (SNCA))

别名

Alpha Synuclein (SNCA 产品)

别名

snca antibody, MGC64356 antibody, LOC619283 antibody, NACP antibody, alphaSYN antibody, PARK1 antibody, PARK4 antibody, PD1 antibody, synuclein alpha L homeolog antibody, alpha-synuclein antibody, synuclein alpha antibody, synuclein, alpha antibody, snca.L antibody, LOC619283 antibody, SNCA antibody, Snca antibody

背景

Alpha-Synuclein (SNCA) is expressed predominantly in the brain, where it is concentrated in presynaptic nerve terminals (1). Alpha-synuclein is highly expressed in the mitochondria of the olfactory bulb, hippocampus, striatum and thalamus (2). Functionally, it has been shown to significantly interact with tubulin (3), and may serve as a potential microtubule-associated protein. It has also been found to be essential for normal development of the cognitive functions, inactivation may lead to impaired spatial learning and working memory (4). SNCA fibrillar aggregates represent the major non A-beta component of Alzheimers disease amyloid plaque, and a major component of Lewy body inclusions, and Parkinson's disease. Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin (5, 6). Alpha synuclein phosphorylated at serine 129 constitutes 90 % of the alpha synuclein found in Lewy bodies (7, 8).

基因ID

6622

NCBI登录号

NP_000336

UniProt

P37840

途径

Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity